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 © 2001-2009, DermAtlas | Image Name: | nevus_sebaceus_1_080129 | File Type: | jpg | |
| Diagnosis: | NEVUS SEBACEUS | Category: | adnexal disorder / neoplasm, adnexal, sebaceous | ||
| Body Site: | face / cheek scalp | Age: | 2 years | ||
| Contributor: | Katherine Puttgen, MD | ||||
| Description: | yellow slightly mamillated plaque in a blaschkoid pattern | ||||
| Comments: | This healthy toddler presented for evaluation of an asymptomatic plaque relatively unchanged since birth | ||||
 © 2001-2009, DermAtlas | Image Name: | sebaceous_adenoma_1_070501 | File Type: | jpg | |
| Diagnosis: | ADENOMA, SEBACEOUS | Category: | neoplasm, adnexal, sebaceous / neoplasm, benign | ||
| Body Site: | face | Age: | 83 years | ||
| Contributor: | Greg Hosler, MD, PhD | ||||
| Description: | There is a basophilic tumor forming nodules within the dermis. Basaloid cells line the periphery of the lobules and mature with sebocytic differentiation toward the center. The lesion is unencapsulated but well-demarcated. Significant cytologic atypia or mitotic activity is not seen. | ||||
| Comments: | This is a typical example of a sebaceous adenoma. It is a benign lesion and often presents as a yellowish papule on the face, as in this case. There is an association with Muir-Torre syndrome, but most cases are sporadic, like this one. | ||||
 © 2001-2009, DermAtlas | Image Name: | sebaceous_adenoma_1_070511 | File Type: | jpg | |
| Diagnosis: | ADENOMA, SEBACEOUS | Category: | neoplasm, adnexal, sebaceous | ||
| Body Site: | neck | Age: | 76 years | ||
| Contributor: | George Wettach, MD | ||||
| Description: | This is a low-magnification image of a hematoxylin and eosin stained section of an erythematous plaque containing a single 4 mm diameter cream colored papule with a central depression. | ||||
| Comments: | A sebaceous adenoma may appear as a yellow papule or nodule, usually located on the face or scalp. These lesions, along with sebaceous epithelioma or sebaceous carcinoma, are often seen in association with Muir-Torre syndrome. The epithelium in this case is otherwise unremarkable with no evidence of carcinoma. | ||||
 © 2001-2009, DermAtlas | Image Name: | sebaceous_carcinoma_1_070417 | File Type: | jpg | |
| Diagnosis: | CARCINOMA, SEBACEOUS | Category: | neoplasm, adnexal, sebaceous / neoplasm, malignant | ||
| Body Site: | chest | Age: | 90 years | ||
| Contributors: | Alde Carlo Gavino, MD Greg Hosler, MD, PhD | ||||
| Description: | Histologic section of skin shows an ulcerated epidermis overlying a lobular dermal proliferation of basaloid cells. There is a dense inflammatory infiltrate surrounding the tumor lobules. | ||||
| Comments: | This 90-year old man presented with a 0.5-centimeter papule on his right outer chest that was thought clinically to be an irritated seborrheic keratosis. Sebaceous carcinoma occurs most commonly in middle-aged or elderly patients. The head and neck, particularly the ocular area, are most prone to developing this neoplasm. It usually presents as an asymptomatic, nondescript nodule. Poorly differentiated cases, such as this one, are particularly treacherous and challenging because majority of the neoplastic cells have lost their sebocytic appearance. The histogenesis of the tumor, however, can be uncovered with careful and close inspection whereby one identifies scattered, albeit very few, cells with the unmistakable appearance of sebocytes. Basaloid (prominent peripheral palisading of neoplastic cells), squamoid (squamous metaplasia with formation of keratin pearls), and sarcomatoid (prominent spindle cells) variants of sebaceous carcinoma have been described. The differential diagnosis includes cutaneous clear cell neoplasms and basal cell carcinoma with sebaceous differentiation. The presence of sebocytes, sometimes aided by their dimorphic staining pattern for cytokeratin and epithelial membrane antigen, clinches the diagnosis. | ||||
| Related Images: | sebaceous_carcinoma_2_070417 | ||||
 © 2001-2009, DermAtlas | Image Name: | sebaceous_carcinoma_2_070417 | File Type: | jpg | |
| Diagnosis: | CARCINOMA, SEBACEOUS | Category: | neoplasm, adnexal, sebaceous / neoplasm, malignant | ||
| Body Site: | chest | Age: | 90 years | ||
| Contributors: | Alde Carlo Gavino, MD Greg Hosler, MD, PhD | ||||
| Description: | Closer inspection reveals the tumor to be composed predominantly of variably atypical basaloid cells exhibiting large and pleomorphic nuclei, discernable nucleoli, and conspicuous mitotic activity. Admixed with these basaloid cells are a few well-differentiated sebocytes. A focus of squamous metaplasia is also present. | ||||
| Comments: | This 90-year old man presented with a 0.5-centimeter papule on his right outer chest that was thought clinically to be an irritated seborrheic keratosis. Sebaceous carcinoma occurs most commonly in middle-aged or elderly patients. The head and neck, particularly the ocular area, are most prone to developing this neoplasm. It usually presents as an asymptomatic, nondescript nodule. Poorly differentiated cases, such as this one, are particularly treacherous and challenging because majority of the neoplastic cells have lost their sebocytic appearance. The histogenesis of the tumor, however, can be uncovered with careful and close inspection whereby one identifies scattered, albeit very few, cells with the unmistakable appearance of sebocytes. Basaloid (prominent peripheral palisading of neoplastic cells), squamoid (squamous metaplasia with formation of keratin pearls), and sarcomatoid (prominent spindle cells) variants of sebaceous carcinoma have been described. The differential diagnosis includes cutaneous clear cell neoplasms and basal cell carcinoma with sebaceous differentiation. The presence of sebocytes, sometimes aided by their dimorphic staining pattern for cytokeratin and epithelial membrane antigen, clinches the diagnosis. | ||||
| Related Images: | sebaceous_carcinoma_1_070417 | ||||
 © 2001-2009, DermAtlas | Image Name: | superficial_epithelioma_1_060313 | File Type: | jpg | |
| Diagnosis: | SUPERFICIAL EPITHELIOMA WITH SEBACEOUS DIFFERENTIATION | Category: | neoplasm, adnexal, sebaceous / neoplasm, benign | ||
| Body Site: | face | Age: | 78 years | ||
| Contributor: | Greg Hosler, MD, PhD | ||||
| Description: | Histologic sections of skin show lobules of sebocytes well distributed along the dermal/epidermal junction, mainly coinciding with tips of rete. There appears to be a rim of keratinocytes confining the lobules to the epidermis. The epidermis is mildy acanthotic but otherwise unremarkable. | ||||
| Comments: | This extremely rare lesion was removed from the temple of a 78-year-old man. It was submitted as a seborrheic keratosis. Superficial epithelioma with sebaceous differentiation was originally reported by Evan Farmer, et al. It often presents on the face as an ill-defined papule or plaque. Seborrheic keratoses often enter into the clinical and histologic differential, as seborrheic keratoses may at times show focal sebaceous differentiation. This lesion shows peculiar yet distinctive histology with lobules of sebocytes scattered at the base of the epidermis. | ||||
| Related Images: | superficial_epithelioma_2_060313 | ||||
 © 2001-2009, DermAtlas | Image Name: | superficial_epithelioma_2_060313 | File Type: | jpg | |
| Diagnosis: | SUPERFICIAL EPITHELIOMA WITH SEBACEOUS DIFFERENTIATION | Category: | neoplasm, adnexal, sebaceous / neoplasm, benign | ||
| Body Site: | face | Age: | 78 years | ||
| Contributor: | Greg Hosler, MD, PhD | ||||
| Description: | Another view of this lesion shows similar findings. The sebocyte lobules extend along the entire length of the 1.0 cm lesion. | ||||
| Comments: | This extremely rare lesion was removed from the temple of a 78-year-old man. It was submitted as a seborrheic keratosis. Superficial epithelioma with sebaceous differentiation was originally reported by Evan Farmer, et al. It often presents on the face as an ill-defined papule or plaque. Seborrheic keratoses often enter into the clinical and histologic differential, as seborrheic keratoses may at times show focal sebaceous differentiation. This lesion shows peculiar yet distinctive histology with lobules of sebocytes scattered at the base of the epidermis. | ||||
| Related Images: | superficial_epithelioma_1_060313 | ||||
 © 2001-2009, DermAtlas | Image Name: | sebaceous_hyperplasia_1_060206 | File Type: | jpg | |
| Diagnosis: | SEBACEOUS HYPERPLASIA | Category: | neoplasm, adnexal, sebaceous / neoplasm, benign | ||
| Body Site: | forehead | Age: | 59 years | ||
| Contributor: | Greg Hosler, MD, PhD | ||||
| Description: | Histologic sections of skin show a proliferation of sebaceous lobules, forming a nodular configuration. The lesion is well-circumscribed and consists of bland, mature-appearing sebocytes. The basaloid cells are confined to the periphery of the lobules. | ||||
| Comments: | This 59-year-old woman developed a papule on her forehead. The clinician submitted this as a nevus. Sebaceous hyperplasia is a benign proliferation of sebaceous glands, often on the face, and often submitted to rule out a nevus or a basal cell carcinoma. Calling this a neoplasm is generous as it typically consists of a few extra sebaceous lobules (usually >3) forming a mass. Although not necessarily a biologic continuum, one can argue a histologic continuum to sebaceous adenoma, "epithelioma" diagnosed by some authors, and sebaceous carcinoma as the proportion of basaloid cells, mitoses, and atypia increases. We will diagnose sebaceous hyperplasia when the clinician clearly biopsied a mass, there are abundant sebaceous lobules, and no malignancy is identified. This is a typical clinical and histologic example of this entity. | ||||
 © 2001-2009, DermAtlas | Image Name: | SebaceousAdenoma_1_060101 | File Type: | jpg | |
| Diagnosis: | ADENOMA, SEBACEOUS | Category: | neoplasm, adnexal, sebaceous / neoplasm, benign | ||
| Body Site: | cheek | Age: | 84 years | ||
| Contributor: | Greg Hosler, MD, PhD | ||||
| Description: | Histologic sections of skin show a well-circumscribed neoplasm consisting of lobules of basophilic cells. Scattered sebocytes are present within the lobules, most prominent at the right of the image. | ||||
| Comments: | This is a solitary lesion on the face of an 84-year-old white woman. It is likely idiopathic, and not indicative of Muir-Torre syndrome. | ||||
| Related Images: | SebaceousAdenoma_2_060101 | ||||
 © 2001-2009, DermAtlas | Image Name: | SebaceousAdenoma_2_060101 | File Type: | jpg | |
| Diagnosis: | ADENOMA, SEBACEOUS | Category: | neoplasm, adnexal, sebaceous / neoplasm, benign | ||
| Body Site: | cheek | Age: | 84 years | ||
| Contributor: | Greg Hosler, MD, PhD | ||||
| Description: | At higher power, the lesion consists of a monomorphic population of bland basaloid cells containing uniformly ovoid nuclei and moderately abundant eosinophilic cytoplasm. Scattered sebocytes are present. Pleomorphism, mitotic activity, and necrosis are not seen. | ||||
| Comments: | This is a solitary lesion on the face of an 84-year-old white woman. It is likely idiopathic, and not indicative of Muir-Torre syndrome. | ||||
| Related Images: | SebaceousAdenoma_1_060101 | ||||
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