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DermAtlas: Histology - lupus erythematosus, discoid
© 2001-2009, DermAtlas
Image Name: dle_1_070501   File Type: jpg
Diagnosis: LUPUS ERYTHEMATOSUS, DISCOID   Category: collagen vascular disease /
hair disorders /
cutaneous sign of systemic disease
Body Site: scalp   Age: 55 years
Contributor: Greg Hosler, MD, PhD    
Description: The epidermis is mildly atrophic with dilated follicles and follicular plugging. An inflammatory infiltrate is also seen, showing a superficial and deep perivascular pattern. There is orthokeratotic hyperkeratosis.
Comments: This is a typical example of discoid lupus erythematosus in the context of scarring alopecia. The differential diagnosis includes the other cicatricial alopecias, such as lichen planopilaris. This biopsy shows a deeper, more intense infiltrate than typically seen with LPP, although it can be difficult to differentiate at times. In tough cases, direct immunofluorescence studies can help.
Related Images: dle_2_070501 

DermAtlas: Histology - lupus erythematosus, discoid
© 2001-2009, DermAtlas
Image Name: dle_2_070501   File Type: jpg
Diagnosis: LUPUS ERYTHEMATOSUS, DISCOID   Category: collagen vascular disease /
hair disorders /
cutaneous sign of systemic disease
Body Site: scalp   Age: 55 years
Contributor: Greg Hosler, MD, PhD    
Description: The epidermis shows basilar vacuolopathy and a thickened eosinophilic basement membrane. There is also pigment incontinence in the papillary dermis.
Comments: This is a typical example of discoid lupus erythematosus in the context of scarring alopecia. The differential diagnosis includes the other cicatricial alopecias, such as lichen planopilaris. This biopsy shows a deeper, more intense infiltrate than typically seen with LPP, although it can be difficult to differentiate at times. In tough cases, direct immunofluorescence studies can help.
Related Images: dle_1_070501 

DermAtlas: FACE - lupus erythematosus
© 2001-2009, DermAtlas
Image Name: Lupus_Erythematousus_1_060407   File Type: jpg
Diagnosis: LUPUS ERYTHEMATOSUS /
LUPUS ERYTHEMATOSUS, DISCOID
  Category: collagen vascular disease /
photosensitivity, photoexacerbated
Body Site: face / cheek
face
  Age: 48 years
Contributor: Kosman Sadek Zikry, MD    
Description: telangiectatis papules and plaques with erythema, crusting, and atrophy
Comments: This 48-year-old woman had discoid lesions for over 10 years with lesions restricted to sun exposed sites. She had large areas of scarring alopecia.
Related Images: All related Images  Lupus_Erythematousus_3_060407  Lupus_Erythematousus_2_060407 

DermAtlas: SCALP - lupus erythematosus
© 2001-2009, DermAtlas
Image Name: Lupus_Erythematousus_2_060407   File Type: jpg
Diagnosis: LUPUS ERYTHEMATOSUS /
LUPUS ERYTHEMATOSUS, DISCOID
  Category: collagen vascular disease /
photosensitivity, photoexacerbated
Body Site: scalp / face   Age: 48 years
Contributor: Kosman Sadek Zikry, MD    
Description: red scaly atrophic and fibrotic hairless plaque
Comments: This 48-year-old woman had discoid lesions for over 10 years with lesions restricted to sun exposed sites. She had large areas of scarring alopecia.
Related Images: All related Images  Lupus_Erythematousus_3_060407  Lupus_Erythematousus_1_060407 

DermAtlas: SCALP - lupus erythematosus
© 2001-2009, DermAtlas
Image Name: Lupus_Erythematousus_3_060407   File Type: jpg
Diagnosis: LUPUS ERYTHEMATOSUS /
LUPUS ERYTHEMATOSUS, DISCOID
  Category: collagen vascular disease /
photosensitivity, photoexacerbated
Body Site: scalp / face   Age: 48 years
Contributor: Kosman Sadek Zikry, MD    
Description: red scaly atrophic and fibrotic hairless plaque
Comments: This 48-year-old woman had discoid lesions for over 10 years with lesions restricted to sun exposed sites. She had large areas of scarring alopecia.
Related Images: All related Images  Lupus_Erythematousus_2_060407  Lupus_Erythematousus_1_060407 

DermAtlas: EAR - lupus erythematosus, discoid
© 2001-2009, DermAtlas
Image Name: discoid_lupus_1_050831   File Type: jpg
Diagnosis: LUPUS ERYTHEMATOSUS, DISCOID /
LUPUS ERYTHEMATOSUS, SYSTEMIC /
LUPUS ERYTHEMATOSUS
  Category: cutaneous sign of systemic disease /
collagen vascular disease /
hyperpigmentation /
photosensitivity, photoexacerbated
Body Site: ear / face
scalp
  Age: 15 years
Contributor: Will Sorey, MD    
Description: symmetric hyperpigmented plaques with scale, central hypopigmentation/depigmentation, follicular plugging, and atrophy
Comments: This adolescent girl had typical discoid lesion on her scalp, face, and ears associated with mild arthopathy and occasional fevers.

DermAtlas: FACE - lupus erythematosus
© 2001-2009, DermAtlas
Image Name: lupus_erythematosus_6_041024   File Type: jpg
Diagnosis: LUPUS ERYTHEMATOSUS /
LUPUS ERYTHEMATOSUS, DISCOID
  Category: collagen vascular disease /
atrophy /
photosensitivity, photoexacerbated
Body Site: face / nose
cheek
  Age: 30 years
Contributor: Kosman Sadek Zikry, MD    
Description: symmetric violaceous round and annular confluent plaques with central crusting and atrophy
Comments: This 30-year-old man complained of disfiguring lesions on the face, scalp and sun exposed areas of the chest, back, and arms. The eruption worsened in summer but improved with oral corticosteroids. He also had scarring alopecia.
Related Images: All related Images  lupus_erythematosus_1_041024  lupus_erythematosus_2_041024  lupus_erythematosus_3_041024  lupus_erythematosus_4_041024  lupus_erythematosus_5_041024 

DermAtlas: FACE - lupus erythematosus
© 2001-2009, DermAtlas
Image Name: lupus_erythematosus_5_041024   File Type: jpg
Diagnosis: LUPUS ERYTHEMATOSUS /
LUPUS ERYTHEMATOSUS, DISCOID
  Category: collagen vascular disease /
atrophy /
photosensitivity, photoexacerbated
Body Site: face / nose
cheek
  Age: 30 years
Contributor: Kosman Sadek Zikry, MD    
Description: symmetric violaceous round and annular confluent plaques with central crusting and atrophy
Comments: This 30-year-old man complained of disfiguring lesions on the face, scalp and sun exposed areas of the chest, back, and arms. The eruption worsened in summer but improved with oral corticosteroids. He also had scarring alopecia.
Related Images: All related Images  lupus_erythematosus_1_041024  lupus_erythematosus_2_041024  lupus_erythematosus_3_041024  lupus_erythematosus_4_041024  lupus_erythematosus_6_041024 

DermAtlas: EAR - lupus erythematosus
© 2001-2009, DermAtlas
Image Name: lupus_erythematosus_4_041024   File Type: jpg
Diagnosis: LUPUS ERYTHEMATOSUS /
LUPUS ERYTHEMATOSUS, DISCOID
  Category: collagen vascular disease /
atrophy /
photosensitivity, photoexacerbated
Body Site: ear   Age: 30 years
Contributor: Kosman Sadek Zikry, MD    
Description: violaceous and hyperpigmented plaques with central atrophy and hypopigmentation
Comments: This 30-year-old man complained of disfiguring lesions on the face, scalp and sun exposed areas of the chest, back, and arms. The eruption worsened in summer but improved with oral corticosteroids. He also had scarring alopecia.
Related Images: All related Images  lupus_erythematosus_1_041024  lupus_erythematosus_2_041024  lupus_erythematosus_3_041024  lupus_erythematosus_5_041024  lupus_erythematosus_6_041024 

DermAtlas: EAR - lupus erythematosus
© 2001-2009, DermAtlas
Image Name: lupus_erythematosus_3_041024   File Type: jpg
Diagnosis: LUPUS ERYTHEMATOSUS /
LUPUS ERYTHEMATOSUS, DISCOID
  Category: collagen vascular disease /
atrophy /
photosensitivity, photoexacerbated
Body Site: ear   Age: 30 years
Contributor: Kosman Sadek Zikry, MD    
Description: violaceous and hyperpigmented plaques with central atrophy and hypopigmentation
Comments: This 30-year-old man complained of disfiguring lesions on the face, scalp and sun exposed areas of the chest, back, and arms. The eruption worsened in summer but improved with oral corticosteroids. He also had scarring alopecia.
Related Images: All related Images  lupus_erythematosus_1_041024  lupus_erythematosus_2_041024  lupus_erythematosus_4_041024  lupus_erythematosus_5_041024  lupus_erythematosus_6_041024 

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© DermAtlas, Johns Hopkins University; 2000-2009
Bernard A. Cohen, MD, Christoph U. Lehmann, MD

DermAtlas was last updated: Oct-28-2009
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