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DermAtlas: FOREARM - leprosy
© 2001-2009, DermAtlas
Image Name: Nerve_abscess_1_090304   File Type: jpg
Diagnosis: LEPROSY   Category: abscess /
infections and infestations /
linear eruptions
Body Site: forearm / hand / wrist   Age: 19 years
Contributor: Piyush Kumar    
Description: linear array of papules and nodules one of which was ulcerated
Comments: This 19-year-old man was evaluated for swelling over the left forearm in a linear distribution for 2 months associated with an ulcer on the wrist for 1 month. The nonhealing ulcer was preceded by a soft nodule. The left ulnar nerve was thickened and tender, and there was loss of sensation in area supplied by the nerve. Atrophy of the instrinsic muscles of the left hand and deformity middle finger were noted. No other nerves were involved. The diagnosis of pure neuritic leprosy with nerve abscess was confirmed by identifying organisms on stains of debris obtained from the ulcer.

DermAtlas: FACE - leprosy
© 2001-2009, DermAtlas
Image Name: Leprosy_1_071207   File Type: jpg
Diagnosis: LEPROSY   Category: infections and infestations
Body Site: face / eye   Age: 19 years
Contributor: Soe Win Oo, MD    
Description: well demarcated violaceous indurated plaques
Comments: A 19-year-old girl was evaluated for violaceous plaques her face for 4 months. She had decresed sensation and weakness when opening and closing and the left eye. Slit skin smears were positive for organisms, and she was diagnosed with borderline leprosy.

DermAtlas: Histology - leprosy
© 2001-2009, DermAtlas
Image Name: leprosy_3_060801   File Type: jpg
Diagnosis: LEPROSY   Category: infections and infestations /
granulomatous disorder
Body Site: knee   Age: 20 years
Contributor: Greg Hosler, MD, PhD    
Description: A modified acid fast stain (FITE) highlights numerous clumps of red bacilli within the granulomatous infiltrate.
Comments: This 20 year-old female grew up in the Marshall Islands. She presented with a red, scaly plaque on her knee. She also reported decreased sensation. The clinican's differential diagnosis was leprosy, psoriasis, or erythema annulare centrifugum. While not so rare in other parts of the world, a good case of leprosy continues to spark excitement here. I should have the pleasure to see more examples as the 9-banded armadillo roams this region (Texas). This is an example of Hansen disease. The presence of numerous acid-fast-positive organisms favors a diagnosis of lepromatous leprosy. This case is probably best classified as borderline lepromatous since the granulomas are a little better formed and there is a sense of neurotropism, features seen in the tuberculous form...cool case.
Related Images: All related Images  leprosy_1_060801  leprosy_2_060801 

DermAtlas: Histology - leprosy
© 2001-2009, DermAtlas
Image Name: leprosy_2_060801   File Type: jpg
Diagnosis: LEPROSY   Category: infections and infestations /
granulomatous disorder
Body Site: knee   Age: 20 years
Contributor: Greg Hosler, MD, PhD    
Description: The histiocytic infiltrate consists of loosely-formed granulomas. The histiocytes are mildly foamy. There is a mild lymphocytic component to the infiltrate. An apparent grenz zone separates the infiltrate from the overlying epidermis.
Comments: This 20 year-old female grew up in the Marshall Islands. She presented with a red, scaly plaque on her knee. She also reported decreased sensation. The clinican's differential diagnosis was leprosy, psoriasis, or erythema annulare centrifugum. While not so rare in other parts of the world, a good case of leprosy continues to spark excitement here. I should have the pleasure to see more examples as the 9-banded armadillo roams this region (Texas). This is an example of Hansen disease. The presence of numerous acid-fast-positive organisms favors a diagnosis of lepromatous leprosy. This case is probably best classified as borderline lepromatous since the granulomas are a little better formed and there is a sense of neurotropism, features seen in the tuberculous form...cool case.
Related Images: All related Images  leprosy_1_060801  leprosy_3_060801 

DermAtlas: Histology - leprosy
© 2001-2009, DermAtlas
Image Name: leprosy_1_060801   File Type: jpg
Diagnosis: LEPROSY   Category: infections and infestations /
granulomatous disorder
Body Site: knee   Age: 20 years
Contributor: Greg Hosler, MD, PhD    
Description: Filling the papillary dermis and extending into the reticular dermis is a nodular granulomatous infiltrate. There is a suggestion of a neurovascular pattern deep within the dermis. The epidermis is unremarkable.
Comments: This 20 year-old female grew up in the Marshall Islands. She presented with a red, scaly plaque on her knee. She also reported decreased sensation. The clinican's differential diagnosis was leprosy, psoriasis, or erythema annulare centrifugum. While not so rare in other parts of the world, a good case of leprosy continues to spark excitement here. I should have the pleasure to see more examples as the 9-banded armadillo roams this region (Texas). This is an example of Hansen disease. The presence of numerous acid-fast-positive organisms favors a diagnosis of lepromatous leprosy. This case is probably best classified as borderline lepromatous since the granulomas are a little better formed and there is a sense of neurotropism, features seen in the tuberculous form...cool case.
Related Images: All related Images  leprosy_2_060801  leprosy_3_060801 

DermAtlas: ARM - leprosy
© 2001-2009, DermAtlas
Image Name: Leprosy_2_060403   File Type: jpg
Diagnosis: LEPROSY /
MYCOBACTERIUM INFECTION
  Category: granulomatous disorder /
infections and infestations
Body Site: arm / leg   Age: 28 days
Contributor: Kosman Sadek Zikry, MD    
Description: indurated hyperpigmented violaceous dermal papules and plaques
Comments: This 28-year-old woman with an 8 year history of biopsy proven leprosy had been on antibiotic therapy for 2 years.
Related Images: All related Images  Leprosy_4_060403  Leprosy_3_060403 

DermAtlas: ARM - leprosy
© 2001-2009, DermAtlas
Image Name: Leprosy_3_060403   File Type: jpg
Diagnosis: LEPROSY /
MYCOBACTERIUM INFECTION
  Category: granulomatous disorder /
infections and infestations
Body Site: arm / leg   Age: 28 days
Contributor: Kosman Sadek Zikry, MD    
Description: indurated hyperpigmented violaceous dermal papules and plaques
Comments: This 28-year-old woman with an 8 year history of biopsy proven leprosy had been on antibiotic therapy for 2 years.
Related Images: All related Images  Leprosy_4_060403  Leprosy_2_060403 

DermAtlas: FACE - leprosy
© 2001-2009, DermAtlas
Image Name: Leprosy_4_060403   File Type: jpg
Diagnosis: LEPROSY /
MYCOBACTERIUM INFECTION
  Category: granulomatous disorder /
infections and infestations
Body Site: face / leg   Age: 28 days
Contributor: Kosman Sadek Zikry, MD    
Description: indurated hyperpigmented violaceous dermal papules with overlying scale
Comments: This 28-year-old woman with an 8 year history of biopsy proven leprosy had been on antibiotic therapy for 2 years.
Related Images: All related Images  Leprosy_3_060403  Leprosy_2_060403 

DermAtlas: LEG - leprosy
© 2001-2009, DermAtlas
Image Name: Leprosy_6_060407   File Type: jpg
Diagnosis: LEPROSY   Category: infections and infestations
Body Site: leg / foot   Age: 35 years
Contributor: Kosman Sadek Zikry, MD    
Description: chronic dermatitic changes, crusts, and foot deformity
Comments: This 35-year-old man had a history of a biopsy proven leprosy for 15 years. He was on systemic antibiotics for many years. Note the chronic recurrent cutaneous injuries and orthopedic deformities resulting from years of progressive neurologic disease.
Related Images: All related Images  Leprosy_1_060407  Leprosy_2_060407  Leprosy_3_060407  Leprosy_4_060407  Leprosy_5_060407 

DermAtlas: LEG - leprosy
© 2001-2009, DermAtlas
Image Name: Leprosy_5_060407   File Type: jpg
Diagnosis: LEPROSY   Category: infections and infestations
Body Site: leg / foot   Age: 35 years
Contributor: Kosman Sadek Zikry, MD    
Description: chronic dermatitic changes, crusts, and foot deformity
Comments: This 35-year-old man had a history of a biopsy proven leprosy for 15 years. He was on systemic antibiotics for many years. Note the chronic recurrent cutaneous injuries and orthopedic deformities resulting from years of progressive neurologic disease.
Related Images: All related Images  Leprosy_1_060407  Leprosy_2_060407  Leprosy_3_060407  Leprosy_4_060407  Leprosy_6_060407 

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© DermAtlas, Johns Hopkins University; 2000-2009
Bernard A. Cohen, MD, Christoph U. Lehmann, MD

DermAtlas was last updated: Oct-28-2009
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