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 © 2001-2009, DermAtlas | Image Name: | eccrine_syringofibroadenoma_1_071101 | File Type: | jpg | |
| Diagnosis: | ECCRINE SYRINGOFIBROADENOMA | Category: | neoplasm, adnexal, eccrine/apocrine / neoplasm, benign | ||
| Body Site: | scalp | Age: | 59 years | ||
| Contributor: | Greg Hosler, MD, PhD | ||||
| Description: | There are numerous thin, anastamosing strands of epithelium coming off multiple points of the epidermis. These are 2-3 cells in thickness and there is a background of fibromucinous stroma. | ||||
| Comments: | Eccrine syringofibroadenoma is a rare tumor of eccrine derivation. Due to the thin, anastamosing strands, the low power differential diagnosis includes a fibroepithelioma of Pinkus and a seborrhiec keratosis, among others. This lesion is benign and shows characteristic eccrine differentiation, such as ductules within the strands. The cells are not cytologically atypical and peritumoral clefting is not seen. | ||||
| Related Images: | eccrine_syringofibroadenoma_2_071101 | ||||
 © 2001-2009, DermAtlas | Image Name: | eccrine_syringofibroadenoma_2_071101 | File Type: | jpg | |
| Diagnosis: | ECCRINE SYRINGOFIBROADENOMA | Category: | neoplasm, adnexal, eccrine/apocrine / neoplasm, benign | ||
| Body Site: | scalp | Age: | 59 years | ||
| Contributor: | Greg Hosler, MD, PhD | ||||
| Description: | There are scattered ductules within the epithelium. The cells are not cytologically atypical and there is no peritumoral clefting. The stroma is fibromucinous and mildly hypercellular. | ||||
| Comments: | Eccrine syringofibroadenoma is a rare tumor of eccrine derivation. Due to the thin, anastamosing strands, the low power differential diagnosis includes a fibroepithelioma of Pinkus and a seborrhiec keratosis, among others. This lesion is benign and shows characteristic eccrine differentiation, such as ductules within the strands. The cells are not cytologically atypical and peritumoral clefting is not seen. | ||||
| Related Images: | eccrine_syringofibroadenoma_1_071101 | ||||
 © 2001-2009, DermAtlas | Image Name: | steatocystoma_multiplex_2_071019 | File Type: | jpg | |
| Diagnosis: | STEATOCYSTOMA MULTIPLEX / STRETCH MARKS / STRIAE DISTENSAE | Category: | neoplasm, adnexal, eccrine/apocrine / neoplasm, benign | ||
| Body Site: | chest / axilla (armpit) abdomen | Age: | 17 years | ||
| Contributor: | Bernard Cohen, MD | ||||
| Description: | multiple symmetric densely grouped yellowish 2-5 mm papules | ||||
| Comments: | This healthy adolescent complained of usually asymptomatic bumps on his chest, abdomen, flank, and axillae increasing over the last 5-6 years. No one else in the family was effected. Occasionally the lesions became inflamed and painful. Note the striae on his shoulders. | ||||
 © 2001-2009, DermAtlas | Image Name: | apocrine_hidrocystoma_1_070501 | File Type: | jpg | |
| Diagnosis: | APOCRINE HIDROCYSTOMA | Category: | cysts / neoplasm, adnexal, eccrine/apocrine | ||
| Body Site: | forehead | Age: | 59 years | ||
| Contributor: | Greg Hosler, MD, PhD | ||||
| Description: | There is a unilocular cyst with a plump, cuboidal cyst lining and foci of decapitation secretion. The cells are cytologically bland. | ||||
| Comments: | Hidrocystomas are fairly common, and often show both eccrine and apocrine features to the lining. We see these most commonly from around the eyes. Whether these represent retention cysts or benign neoplasms is controversial. When these lesions become more complex with papillary structures and increased cellularity, we can use the term cystadenoma. | ||||
 © 2001-2009, DermAtlas | Image Name: | cylindroma_1_070416 | File Type: | jpg | |
| Diagnosis: | CYLINDROMA | Category: | neoplasm, adnexal, eccrine/apocrine / neoplasm, benign | ||
| Body Site: | scalp | Age: | 63 years | ||
| Contributors: | Alde Carlo Gavino, MD Greg Hosler, MD, PhD | ||||
| Description: | Histologic section of skin shows a dermal nodule composed of lobules of basaloid cells arranged in a characteristic jigsaw or mosaic pattern and separated by thick hyalinized basement membrane-like material. The nodule is not encapsulated and has no connection with the epidermis. | ||||
| Comments: | This 63-year old woman presented with a 1.0-centimeter nodule on her scalp. Cylindroma is a benign adnexal neoplasm that most commonly affects women in the third to fifth decades of life. There is a marked preponderance for this tumor to occur on the head, neck, and scalp. It is usually asymptomatic, grows slowly, and averages 1 centimeter in size. Multiple cylindromas may occur with eccrine spiradenomas and trichoepitheliomas in the autosomal dominant Brooke-Spiegler syndrome (familial cylindromatosis or turban tumor syndrome). Both the sporadic and familial forms of cylindroma have been shown to result from inactivation of the CYLD tumor suppressor gene in chromosome 16q12-q13. The basement membrane-like material within and surrounding the tumor lobules are composed of proteins found normally at the dermal-epidermal junction and are thought to result from defective processing of laminin 5 by the tumor cells. The main differential diagnosis of cylindroma is its cousin eccrine spiradenoma. The latter tumor is distinguished from cylindroma by its fewer but larger tumor lobules and by the prominence of dilated vascular spaces within these lobules. | ||||
| Related Images: | cylindroma_2_070416 | ||||
 © 2001-2009, DermAtlas | Image Name: | cylindroma_2_070416 | File Type: | jpg | |
| Diagnosis: | CYLINDROMA | Category: | neoplasm, adnexal, eccrine/apocrine / neoplasm, benign | ||
| Body Site: | scalp | Age: | 63 years | ||
| Contributors: | Alde Carlo Gavino, MD Greg Hosler, MD, PhD | ||||
| Description: | Higher power view reveals the tumor lobules to be composed of two distinct populations of cells: smaller palisaded basaloid cells in the periphery surrounding larger cells with pale cytoplasm and vesicular nuclei. Admixed with the tumor cells are variable amounts of hyaline droplets of similar quality to the basement membrane-like material bordering the lobules. | ||||
| Comments: | This 63-year old woman presented with a 1.0-centimeter nodule on her scalp. Cylindroma is a benign adnexal neoplasm that most commonly affects women in the third to fifth decades of life. There is a marked preponderance for this tumor to occur on the head, neck, and scalp. It is usually asymptomatic, grows slowly, and averages 1 centimeter in size. Multiple cylindromas may occur with eccrine spiradenomas and trichoepitheliomas in the autosomal dominant Brooke-Spiegler syndrome (familial cylindromatosis or turban tumor syndrome). Both the sporadic and familial forms of cylindroma have been shown to result from inactivation of the CYLD tumor suppressor gene in chromosome 16q12-q13. The basement membrane-like material within and surrounding the tumor lobules are composed of proteins found normally at the dermal-epidermal junction and are thought to result from defective processing of laminin 5 by the tumor cells. The main differential diagnosis of cylindroma is its cousin eccrine spiradenoma. The latter tumor is distinguished from cylindroma by its fewer but larger tumor lobules and by the prominence of dilated vascular spaces within these lobules. | ||||
| Related Images: | cylindroma_1_070416 | ||||
 © 2001-2009, DermAtlas | Image Name: | dermal_duct_tumor_1_061101 | File Type: | jpg | |
| Diagnosis: | DERMAL DUCT TUMOR / ECCRINE ACROSPIROMA | Category: | neoplasm, adnexal, eccrine/apocrine / neoplasm, benign | ||
| Body Site: | leg | Age: | 76 years | ||
| Contributor: | Greg Hosler, MD, PhD | ||||
| Description: | There is an epithelial proliferation, confined to the dermis. The proliferation consists of large lobules of monomorphic cells. Ductules can be found. There are also foci of hyalinized stroma. | ||||
| Comments: | The dermal duct tumor is in the category of poroma. It essentially is a poroma but is thought to originate deeper along the eccrine duct. It does not rain off the epidermis like the typical poroma, only shows large dermal nodules, as in this case. The dermal duct tumor is rare, and given enough levels, an epidermal attachment is often found, prompting some pathologists to call these "acrospiromas" of the poroma family. | ||||
| Related Images: | dermal_duct_tumor_2_061101 | ||||
 © 2001-2009, DermAtlas | Image Name: | dermal_duct_tumor_2_061101 | File Type: | jpg | |
| Diagnosis: | DERMAL DUCT TUMOR / ECCRINE ACROSPIROMA | Category: | neoplasm, adnexal, eccrine/apocrine / neoplasm, benign | ||
| Body Site: | leg | Age: | 76 years | ||
| Contributor: | Greg Hosler, MD, PhD | ||||
| Description: | This close-up shows the typical eccrine poroma cytomorphology. The proliferation is monotonous and bland. Mitoses and atypia are rare. | ||||
| Comments: | The dermal duct tumor is in the category of poroma. It essentially is a poroma but is thought to originate deeper along the eccrine duct. It does not rain off the epidermis like the typical poroma, only shows large dermal nodules, as in this case. The dermal duct tumor is rare, and given enough levels, an epidermal attachment is often found, prompting some pathologists to call these "acrospiromas" of the poroma family. | ||||
| Related Images: | dermal_duct_tumor_1_061101 | ||||
 © 2001-2009, DermAtlas | Image Name: | papillary_eccrine_adenoma_1_061101 | File Type: | jpg | |
| Diagnosis: | ADENOMA, PAPILLARY ECCRINE | Category: | neoplasm, adnexal, eccrine/apocrine / neoplasm, benign | ||
| Body Site: | hand | Age: | 44 years | ||
| Contributor: | Greg Hosler, MD, PhD | ||||
| Description: | There is a tubular/glandular proliferation confined to the dermis. The lesion appears well-demarcated and symmetric. The glands are lined by cytologically bland cells. Focally, there are thin papillary projections into the lumen. | ||||
| Comments: | The papillary eccrine adenoma often occurs on the distal extremities of African-American women, as in this case. It is a benign lesion of eccrine origin. Some cases show more papillary projections, but otherwise this shows classic features. | ||||
| Related Images: | papillary_eccrine_adenoma_2_061101 | ||||
 © 2001-2009, DermAtlas | Image Name: | papillary_eccrine_adenoma_2_061101 | File Type: | jpg | |
| Diagnosis: | ADENOMA, PAPILLARY ECCRINE | Category: | neoplasm, adnexal, eccrine/apocrine / neoplasm, benign | ||
| Body Site: | hand | Age: | 44 years | ||
| Contributor: | Greg Hosler, MD, PhD | ||||
| Description: | The glandular spaces are lined by two layers of low cuboidal cells. Few papillae project into the lumen, Atypia and mitotic activity are not seen. | ||||
| Comments: | The papillary eccrine adenoma often occurs on the distal extremities of African-American women, as in this case. It is a benign lesion of eccrine origin. Some cases show more papillary projections, but otherwise this shows classic features. | ||||
| Related Images: | papillary_eccrine_adenoma_1_061101 | ||||
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