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 © 2001-2009, DermAtlas | Image Name: | angioleiomyoma_1_090401 | File Type: | jpg | |
| Diagnosis: | ANGIOLEIOMYOMA | Category: | neoplasm, muscle / neoplasm, benign | ||
| Body Site: | ankle | Age: | 35 years | ||
| Contributor: | Greg Hosler, MD, PhD | ||||
| Description: | There is a well-circumscribed solitary nodule within the deep dermis on acral skin. It is brightly eosinophilic and consists of spindled cells. | ||||
| Comments: | This 35 year old woman had a long-standing solitary mass on her ankle. It was mildly painful. It was biopsied as a possible cyst or glomus tumor. Angioleiomyomas are the "pink balls in the dermis" and also part of the painful skin lesion mneumonic. This is a typical example with a very distinctive look, arising from the deep dermal and subcutaneous vessel walls. The vessels may not be a prominent component as they are often collapsed. Some variants are cellular. These are easily differentiated from piloleiomyomas, which at low power ramify through collagen bundles instead of having circumscription. | ||||
| Related Images: | angioleiomyoma_2_090401 | ||||
 © 2001-2009, DermAtlas | Image Name: | angioleiomyoma_2_090401 | File Type: | jpg | |
| Diagnosis: | ANGIOLEIOMYOMA | Category: | neoplasm, muscle / neoplasm, benign | ||
| Body Site: | ankle | Age: | 35 years | ||
| Contributor: | Greg Hosler, MD, PhD | ||||
| Description: | The cells have short, blunt-ended nuclei and abundant pink cytoplasm. When cut in cross-section, there are perinuclear vacuoles. The vessels are fairly inconspicuous. There is no cytologic atypia or mitotic activity. | ||||
| Comments: | This 35 year old woman had a long-standing solitary mass on her ankle. It was mildly painful. It was biopsied as a possible cyst or glomus tumor. Angioleiomyomas are the "pink balls in the dermis" and also part of the painful skin lesion mneumonic. This is a typical example with a very distinctive look, arising from the deep dermal and subcutaneous vessel walls. The vessels may not be a prominent component as they are often collapsed. Some variants are cellular. These are easily differentiated from piloleiomyomas, which at low power ramify through collagen bundles instead of having circumscription. | ||||
| Related Images: | angioleiomyoma_1_090401 | ||||
 © 2001-2009, DermAtlas | Image Name: | angioleiomyoma_1_070423 | File Type: | jpg | |
| Diagnosis: | ANGIOLEIOMYOMA | Category: | neoplasm, muscle / neoplasm, vascular / neoplasm, benign | ||
| Body Site: | leg | Age: | 59 years | ||
| Contributors: | Alde Carlo Gavino, MD Greg Hosler, MD, PhD | ||||
| Description: | Histologic section of skin shows a fairly well-circumscribed dermal nodule consisting of fascicles of banal smooth muscle cells surrounding an aggregate of thick-walled vessels. There is a mild inflammatory infiltrate. | ||||
| Comments: | This 59-year old woman presented with a 0.6-centimeter nodule on her left lower leg that was thought clinically to be a poroma versus a cyst versus a dermatofibroma. This is a classic presentation of angioleiomyoma in that it most commonly presents as a solitary lesion on the lower leg or feet of adult women. The lesion is usually painful. Angioleiomyoma must be distinguished from leiomyosarcoma (prominent cytologic atypia), other smooth muscle tumors such as pilar leiomyoma, and vascular anomalies. The proliferation of benign smooth muscle fibers and the way they emerge from the walls of intimately associated blood vessels in angioleiomyoma differentiate the latter from its mimics. | ||||
| Related Images: | angioleiomyoma_2_070423 | ||||
 © 2001-2009, DermAtlas | Image Name: | angioleiomyoma_2_070423 | File Type: | jpg | |
| Diagnosis: | ANGIOLEIOMYOMA | Category: | neoplasm, muscle / neoplasm, vascular / neoplasm, benign | ||
| Body Site: | leg | Age: | 59 years | ||
| Contributors: | Alde Carlo Gavino, MD Greg Hosler, MD, PhD | ||||
| Description: | Higher power view demonstrates the intimate relationship of the spindle cells to the blood vessels, indicating the origin of the former from the latter. The vascular lumina are compressed. | ||||
| Comments: | This 59-year old woman presented with a 0.6-centimeter nodule on her left lower leg that was thought clinically to be a poroma versus a cyst versus a dermatofibroma. This is a classic presentation of angioleiomyoma in that it most commonly presents as a solitary lesion on the lower leg or feet of adult women. The lesion is usually painful. Angioleiomyoma must be distinguished from leiomyosarcoma (prominent cytologic atypia), other smooth muscle tumors such as pilar leiomyoma, and vascular anomalies. The proliferation of benign smooth muscle fibers and the way they emerge from the walls of intimately associated blood vessels in angioleiomyoma differentiate the latter from its mimics. | ||||
| Related Images: | angioleiomyoma_1_070423 | ||||
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