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 © 2001-2009, DermAtlas | Image Name: | MITOMYCIN_8_090828 | File Type: | jpg | |
| Diagnosis: | DRUG REACTION, ECZEMATOUS / MITOMYCIN C DRUG REACTION | Category: | drug reaction | ||
| Body Site: | total body / hand | Age: | 72 years | ||
| Contributor: | Andrei Botnaru | ||||
| Description: | generalized red, scaly, crusted, excoriated eczematous patches | ||||
| Comments: | This 72-year-old man developed a generalized eczematous eruption after the fifth intravesical instillation of mitomycin C for treatment of transitional cell carcinoma of the bladder following endoscopic resection of the tumor.Repeated intravesical instillations of this alkylating agent can induce cystitis and an eczematous eruption affecting the palms, soles and face. If these effects are due to a delayed hypersensitivity with sensitization to mitomycin C occurring in the bladder, it should be possible to demonstrate antigen-presenting cells in the bladder wall. Positive patch testing in sensitized patients has been reported suggesting that the eczematous eruption most likely represents a type IV delayed hypersensitivity reaction that is mediated transvesically. Discontinuation of the drug results in clearing of the skin eruption. Dermatologists and anyone involved in the treatment of these patients should be aware of this complication of therapy. (Kunkeler L, Nieboer C, Bruynzeel DP. Type III and type IV hypersensitivity reactions due to mitomycin C.Contact Dermatitis. 2000 Feb;42(2):74-6) | ||||
| Related Images: | All related Images MITOMYCIN_1_090828 MITOMYCIN_2_090828 MITOMYCIN_3_090828 MITOMYCIN_5_090828 MITOMYCIN_6_090828 MITOMYCIN_7_090828 | ||||
 © 2001-2009, DermAtlas | Image Name: | MITOMYCIN_7_090828 | File Type: | jpg | |
| Diagnosis: | DRUG REACTION, ECZEMATOUS / MITOMYCIN C DRUG REACTION | Category: | drug reaction | ||
| Body Site: | total body / leg | Age: | 72 years | ||
| Contributor: | Andrei Botnaru | ||||
| Description: | generalized red, scaly, crusted, excoriated eczematous patches | ||||
| Comments: | This 72-year-old man developed a generalized eczematous eruption after the fifth intravesical instillation of mitomycin C for treatment of transitional cell carcinoma of the bladder following endoscopic resection of the tumor.Repeated intravesical instillations of this alkylating agent can induce cystitis and an eczematous eruption affecting the palms, soles and face. If these effects are due to a delayed hypersensitivity with sensitization to mitomycin C occurring in the bladder, it should be possible to demonstrate antigen-presenting cells in the bladder wall. Positive patch testing in sensitized patients has been reported suggesting that the eczematous eruption most likely represents a type IV delayed hypersensitivity reaction that is mediated transvesically. Discontinuation of the drug results in clearing of the skin eruption. Dermatologists and anyone involved in the treatment of these patients should be aware of this complication of therapy. (Kunkeler L, Nieboer C, Bruynzeel DP. Type III and type IV hypersensitivity reactions due to mitomycin C.Contact Dermatitis. 2000 Feb;42(2):74-6) | ||||
| Related Images: | All related Images MITOMYCIN_1_090828 MITOMYCIN_2_090828 MITOMYCIN_3_090828 MITOMYCIN_5_090828 MITOMYCIN_6_090828 MITOMYCIN_8_090828 | ||||
 © 2001-2009, DermAtlas | Image Name: | MITOMYCIN_6_090828 | File Type: | jpg | |
| Diagnosis: | DRUG REACTION, ECZEMATOUS / MITOMYCIN C DRUG REACTION | Category: | drug reaction | ||
| Body Site: | total body / finger | Age: | 72 years | ||
| Contributor: | Andrei Botnaru | ||||
| Description: | generalized red, scaly, crusted, excoriated eczematous patches | ||||
| Comments: | This 72-year-old man developed a generalized eczematous eruption after the fifth intravesical instillation of mitomycin C for treatment of transitional cell carcinoma of the bladder following endoscopic resection of the tumor.Repeated intravesical instillations of this alkylating agent can induce cystitis and an eczematous eruption affecting the palms, soles and face. If these effects are due to a delayed hypersensitivity with sensitization to mitomycin C occurring in the bladder, it should be possible to demonstrate antigen-presenting cells in the bladder wall. Positive patch testing in sensitized patients has been reported suggesting that the eczematous eruption most likely represents a type IV delayed hypersensitivity reaction that is mediated transvesically. Discontinuation of the drug results in clearing of the skin eruption. Dermatologists and anyone involved in the treatment of these patients should be aware of this complication of therapy. (Kunkeler L, Nieboer C, Bruynzeel DP. Type III and type IV hypersensitivity reactions due to mitomycin C.Contact Dermatitis. 2000 Feb;42(2):74-6) | ||||
| Related Images: | All related Images MITOMYCIN_1_090828 MITOMYCIN_2_090828 MITOMYCIN_3_090828 MITOMYCIN_5_090828 MITOMYCIN_7_090828 MITOMYCIN_8_090828 | ||||
 © 2001-2009, DermAtlas | Image Name: | MITOMYCIN_5_090828 | File Type: | jpg | |
| Diagnosis: | DRUG REACTION, ECZEMATOUS / MITOMYCIN C DRUG REACTION | Category: | drug reaction | ||
| Body Site: | total body / arm | Age: | 72 years | ||
| Contributor: | Andrei Botnaru | ||||
| Description: | generalized red, scaly, crusted, excoriated eczematous patches | ||||
| Comments: | This 72-year-old man developed a generalized eczematous eruption after the fifth intravesical instillation of mitomycin C for treatment of transitional cell carcinoma of the bladder following endoscopic resection of the tumor.Repeated intravesical instillations of this alkylating agent can induce cystitis and an eczematous eruption affecting the palms, soles and face. If these effects are due to a delayed hypersensitivity with sensitization to mitomycin C occurring in the bladder, it should be possible to demonstrate antigen-presenting cells in the bladder wall. Positive patch testing in sensitized patients has been reported suggesting that the eczematous eruption most likely represents a type IV delayed hypersensitivity reaction that is mediated transvesically. Discontinuation of the drug results in clearing of the skin eruption. Dermatologists and anyone involved in the treatment of these patients should be aware of this complication of therapy. (Kunkeler L, Nieboer C, Bruynzeel DP. Type III and type IV hypersensitivity reactions due to mitomycin C.Contact Dermatitis. 2000 Feb;42(2):74-6) | ||||
| Related Images: | All related Images MITOMYCIN_1_090828 MITOMYCIN_2_090828 MITOMYCIN_3_090828 MITOMYCIN_6_090828 MITOMYCIN_7_090828 MITOMYCIN_8_090828 | ||||
 © 2001-2009, DermAtlas | Image Name: | MITOMYCIN_3_090828 | File Type: | jpg | |
| Diagnosis: | DRUG REACTION, ECZEMATOUS / MITOMYCIN C DRUG REACTION | Category: | drug reaction | ||
| Body Site: | total body / leg | Age: | 72 years | ||
| Contributor: | Andrei Botnaru | ||||
| Description: | generalized red, scaly, crusted, excoriated eczematous patches | ||||
| Comments: | This 72-year-old man developed a generalized eczematous eruption after the fifth intravesical instillation of mitomycin C for treatment of transitional cell carcinoma of the bladder following endoscopic resection of the tumor.Repeated intravesical instillations of this alkylating agent can induce cystitis and an eczematous eruption affecting the palms, soles and face. If these effects are due to a delayed hypersensitivity with sensitization to mitomycin C occurring in the bladder, it should be possible to demonstrate antigen-presenting cells in the bladder wall. Positive patch testing in sensitized patients has been reported suggesting that the eczematous eruption most likely represents a type IV delayed hypersensitivity reaction that is mediated transvesically. Discontinuation of the drug results in clearing of the skin eruption. Dermatologists and anyone involved in the treatment of these patients should be aware of this complication of therapy. (Kunkeler L, Nieboer C, Bruynzeel DP. Type III and type IV hypersensitivity reactions due to mitomycin C.Contact Dermatitis. 2000 Feb;42(2):74-6) | ||||
| Related Images: | All related Images MITOMYCIN_1_090828 MITOMYCIN_2_090828 MITOMYCIN_5_090828 MITOMYCIN_6_090828 MITOMYCIN_7_090828 MITOMYCIN_8_090828 | ||||
 © 2001-2009, DermAtlas | Image Name: | MITOMYCIN_2_090828 | File Type: | jpg | |
| Diagnosis: | DRUG REACTION, ECZEMATOUS / MITOMYCIN C DRUG REACTION | Category: | drug reaction | ||
| Body Site: | total body / hand | Age: | 72 years | ||
| Contributor: | Andrei Botnaru | ||||
| Description: | generalized red, scaly, crusted, excoriated eczematous patches | ||||
| Comments: | This 72-year-old man developed a generalized eczematous eruption after the fifth intravesical instillation of mitomycin C for treatment of transitional cell carcinoma of the bladder following endoscopic resection of the tumor.Repeated intravesical instillations of this alkylating agent can induce cystitis and an eczematous eruption affecting the palms, soles and face. If these effects are due to a delayed hypersensitivity with sensitization to mitomycin C occurring in the bladder, it should be possible to demonstrate antigen-presenting cells in the bladder wall. Positive patch testing in sensitized patients has been reported suggesting that the eczematous eruption most likely represents a type IV delayed hypersensitivity reaction that is mediated transvesically. Discontinuation of the drug results in clearing of the skin eruption. Dermatologists and anyone involved in the treatment of these patients should be aware of this complication of therapy. (Kunkeler L, Nieboer C, Bruynzeel DP. Type III and type IV hypersensitivity reactions due to mitomycin C.Contact Dermatitis. 2000 Feb;42(2):74-6) | ||||
| Related Images: | All related Images MITOMYCIN_1_090828 MITOMYCIN_3_090828 MITOMYCIN_5_090828 MITOMYCIN_6_090828 MITOMYCIN_7_090828 MITOMYCIN_8_090828 | ||||
 © 2001-2009, DermAtlas | Image Name: | MITOMYCIN_1_090828 | File Type: | jpg | |
| Diagnosis: | DRUG REACTION, ECZEMATOUS / MITOMYCIN C DRUG REACTION | Category: | drug reaction | ||
| Body Site: | total body / leg | Age: | 72 years | ||
| Contributor: | Andrei Botnaru | ||||
| Description: | generalized red, scaly, crusted, excoriated eczematous patches | ||||
| Comments: | This 72-year-old man developed a generalized eczematous eruption after the fifth intravesical instillation of mitomycin C for treatment of transitional cell carcinoma of the bladder following endoscopic resection of the tumor.Repeated intravesical instillations of this alkylating agent can induce cystitis and an eczematous eruption affecting the palms, soles and face. If these effects are due to a delayed hypersensitivity with sensitization to mitomycin C occurring in the bladder, it should be possible to demonstrate antigen-presenting cells in the bladder wall. Positive patch testing in sensitized patients has been reported suggesting that the eczematous eruption most likely represents a type IV delayed hypersensitivity reaction that is mediated transvesically. Discontinuation of the drug results in clearing of the skin eruption. Dermatologists and anyone involved in the treatment of these patients should be aware of this complication of therapy. (Kunkeler L, Nieboer C, Bruynzeel DP. Type III and type IV hypersensitivity reactions due to mitomycin C.Contact Dermatitis. 2000 Feb;42(2):74-6) | ||||
| Related Images: | All related Images MITOMYCIN_2_090828 MITOMYCIN_3_090828 MITOMYCIN_5_090828 MITOMYCIN_6_090828 MITOMYCIN_7_090828 MITOMYCIN_8_090828 | ||||
 © 2001-2009, DermAtlas | Image Name: | chemical_burn_1_090816 | File Type: | jpg | |
| Diagnosis: | BURN, CHEMICAL / EX-LAX INDUCED CHEMICAL BURN | Category: | drug reaction / environmental injury | ||
| Body Site: | buttock / genital vulva (labia) / diaper area | Age: | 2 years | ||
| Contributor: | Randy Cordle, MD | ||||
| Description: | large well-demarcated symmetric red patches with scattered bullae | ||||
| Comments: | This 2-year-old girl developed large diarrheal stools and a chemical burn on her buttocks, perineum, and genital area after getting into her mother's laxative medication. The night before she had eaten 5 Ex-Lax tablets (Sennosides chewable tablets, 25 mg). Chemical burns from diarrhea resulting from ingestion of laxatives was reported by the author in Pediatrics, July 22, 2009, pp 179-80. The report emphasizes the importance of distinguishing this process from non-accidental injuries caused by hot water. | ||||
| Related Images: | chemical_burn_2_090816 | ||||
 © 2001-2009, DermAtlas | Image Name: | chemical_burn_2_090816 | File Type: | jpg | |
| Diagnosis: | BURN, CHEMICAL / EX-LAX INDUCED CHEMICAL BURN | Category: | drug reaction / environmental injury | ||
| Body Site: | buttock / genital vulva (labia) / diaper area | Age: | 2 years | ||
| Contributor: | Randy Cordle, MD | ||||
| Description: | large well-demarcated symmetric red patches with scattered bullae | ||||
| Comments: | This 2-year-old girl developed large diarrheal stools and a chemical burn on her buttocks, perineum, and genital area after getting into her mother's laxative medication. The night before she had eaten 5 Ex-Lax tablets (Sennosides chewable tablets, 25 mg). Chemical burns from diarrhea resulting from ingestion of laxatives was reported by the author in Pediatrics, July 22, 2009, pp 179-80. The report emphasizes the importance of distinguishing this process from non-accidental injuries caused by hot water. | ||||
| Related Images: | chemical_burn_1_090816 | ||||
 © 2001-2009, DermAtlas | Image Name: | fixed_drug_reaction_1_090731 | File Type: | jpg | |
| Diagnosis: | DRUG REACTION, FIXED / DRUG REACTION / DRUG REACTION, ALLOPURINOL | Category: | drug reaction / hyperpigmentation | ||
| Body Site: | leg / thigh | Age: | 63 years | ||
| Contributor: | Sherry Guralnick Cohen, CRNP-F | ||||
| Description: | grayish brown 1-3 cm round patches | ||||
| Comments: | This 63-year-old woman developed itchy purple plaques on her thighs 3 weeks after starting allopurinol for gout. The inflammation and itching gradually resolved when the medication was discontinued leaving residual hyperpigmented macules. | ||||
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