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 © 2001-2009, DermAtlas | Image Name: | Crest_syndrome_1_090828 | File Type: | jpg | |
| Diagnosis: | CREST SYNDROME / SCLERODERMA | Category: | lumps & bumps (plaques, nodules, tumors) / collagen vascular disease | ||
| Body Site: | thumb / finger | Age: | 60 years | ||
| Contributor: | Nikolaos Sferopoulos, MD | ||||
| Description: | tender 1 cm nodule with central white chalky papule | ||||
| Comments: | A 60-year-old woman was referred for a painful lesion of the tip of her right thumb. Radiographs indicated diffuse sclerotic lesions in the soft tissues of the distal phalanx of her thumb. She reported an over 15-year-history of Raynaud phenomenon and positive antinuclear antibody titer. The lesion was surgically debrided under local anaesthesia but the borders could not be identified. Biopsy showed localized calcinosis cutis. The patient was referred to rheumatology where the diagnosis of Crest syndrome was made. Two weeks later the sutures were removed, and the scar was ruptured because of residual calcinosis in the soft tissues. By that time the borders of the lesions were easily identified and removed. No residual clinical lesion was evident 2 months post operatively despite radiographic evidence of persistent calcinosis. | ||||
| Related Images: | Crest_syndrome_2_090828 | ||||
 © 2001-2009, DermAtlas | Image Name: | Crest_syndrome_2_090828 | File Type: | jpg | |
| Diagnosis: | CREST SYNDROME / SCLERODERMA | Category: | lumps & bumps (plaques, nodules, tumors) / collagen vascular disease | ||
| Body Site: | thumb / finger | Age: | 60 years | ||
| Contributor: | Nikolaos Sferopoulos, MD | ||||
| Description: | tender 1 cm nodule with central white chalky papule | ||||
| Comments: | A 60-year-old woman was referred for a painful lesion of the tip of her right thumb. Radiographs indicated diffuse sclerotic lesions in the soft tissues of the distal phalanx of her thumb. She reported an over 15-year-history of Raynaud phenomenon and positive antinuclear antibody titer. The lesion was surgically debrided under local anaesthesia but the borders could not be identified. Biopsy showed localized calcinosis cutis. The patient was referred to rheumatology where the diagnosis of Crest syndrome was made. Two weeks later the sutures were removed, and the scar was ruptured because of residual calcinosis in the soft tissues. By that time the borders of the lesions were easily identified and removed. No residual clinical lesion was evident 2 months post operatively despite radiographic evidence of persistent calcinosis. | ||||
| Related Images: | Crest_syndrome_1_090828 | ||||
 © 2001-2009, DermAtlas | Image Name: | drug_induced_lupus_1_090418 | File Type: | jpg | |
| Diagnosis: | LUPUS ERYTHEMATOSUS / LUPUS ERYTHEMATOSUS, DRUG INDUCED / DRUG REACTION | Category: | drug reaction / collagen vascular disease | ||
| Body Site: | total body / arm chest | Age: | 25 years | ||
| Contributor: | Amr Gohar, MRCPS Glasgow | ||||
| Description: | generalized discrete and confluent annular red papules and plaques with peripheral scale | ||||
| Comments: | A 25-year-old man developed a recurrent annular erythematous eruption with peripheral scaling over several months. When lesions temporarily resolved, they left greyish discoloration. The differential diagnosis included erythema annulare centrifugum, pityriasis rosea (when first seen with few lesions) , and subacute cutaneous lupus erythematosus. Initially the patient forgot that he was taking a drug for dyspepsia. Later it was found to be Lansoprazole. Skin biopsy shows hyperorthokeratosis, epidermal atrophy, hydropic degeneration of the basal cell layer, and lymphocytic infiltrate of the superficial dermis consistent with lupus. The antinuclear antibodt was positive at 1:80, while anti-Ro and anti-La antibodies were negative. Discontinuation of the Lansoprazole resulted in a complete clearance of the rash within few weeks. The pigmentary changes resolved completely. There was no recurrence of the skin lesions during a follow up period of one year. The course was typical for drug-induced lupus. | ||||
| Related Images: | All related Images drug_induced_lupus_6_090418 drug_induced_lupus_5_090418 drug_induced_lupus_4_090418 drug_induced_lupus_3_090418 drug_induced_lupus_2_090418 | ||||
 © 2001-2009, DermAtlas | Image Name: | drug_induced_lupus_2_090418 | File Type: | jpg | |
| Diagnosis: | LUPUS ERYTHEMATOSUS / LUPUS ERYTHEMATOSUS, DRUG INDUCED / DRUG REACTION | Category: | drug reaction / collagen vascular disease | ||
| Body Site: | total body / arm chest / abdomen | Age: | 25 years | ||
| Contributor: | Amr Gohar, MRCPS Glasgow | ||||
| Description: | generalized discrete and confluent annular red papules and plaques with peripheral scale | ||||
| Comments: | A 25-year-old man developed a recurrent annular erythematous eruption with peripheral scaling over several months. When lesions temporarily resolved, they left greyish discoloration. The differential diagnosis included erythema annulare centrifugum, pityriasis rosea (when first seen with few lesions) , and subacute cutaneous lupus erythematosus. Initially the patient forgot that he was taking a drug for dyspepsia. Later it was found to be Lansoprazole. Skin biopsy shows hyperorthokeratosis, epidermal atrophy, hydropic degeneration of the basal cell layer, and lymphocytic infiltrate of the superficial dermis consistent with lupus. The antinuclear antibodt was positive at 1:80, while anti-Ro and anti-La antibodies were negative. Discontinuation of the Lansoprazole resulted in a complete clearance of the rash within few weeks. The pigmentary changes resolved completely. There was no recurrence of the skin lesions during a follow up period of one year. The course was typical for drug-induced lupus. | ||||
| Related Images: | All related Images drug_induced_lupus_6_090418 drug_induced_lupus_5_090418 drug_induced_lupus_4_090418 drug_induced_lupus_3_090418 drug_induced_lupus_1_090418 | ||||
 © 2001-2009, DermAtlas | Image Name: | drug_induced_lupus_3_090418 | File Type: | jpg | |
| Diagnosis: | LUPUS ERYTHEMATOSUS / LUPUS ERYTHEMATOSUS, DRUG INDUCED / DRUG REACTION | Category: | drug reaction / collagen vascular disease | ||
| Body Site: | total body / back | Age: | 25 years | ||
| Contributor: | Amr Gohar, MRCPS Glasgow | ||||
| Description: | generalized discrete and confluent annular red papules and plaques with peripheral scale | ||||
| Comments: | A 25-year-old man developed a recurrent annular erythematous eruption with peripheral scaling over several months. When lesions temporarily resolved, they left greyish discoloration. The differential diagnosis included erythema annulare centrifugum, pityriasis rosea (when first seen with few lesions) , and subacute cutaneous lupus erythematosus. Initially the patient forgot that he was taking a drug for dyspepsia. Later it was found to be Lansoprazole. Skin biopsy shows hyperorthokeratosis, epidermal atrophy, hydropic degeneration of the basal cell layer, and lymphocytic infiltrate of the superficial dermis consistent with lupus. The antinuclear antibodt was positive at 1:80, while anti-Ro and anti-La antibodies were negative. Discontinuation of the Lansoprazole resulted in a complete clearance of the rash within few weeks. The pigmentary changes resolved completely. There was no recurrence of the skin lesions during a follow up period of one year. The course was typical for drug-induced lupus. | ||||
| Related Images: | All related Images drug_induced_lupus_6_090418 drug_induced_lupus_5_090418 drug_induced_lupus_4_090418 drug_induced_lupus_2_090418 drug_induced_lupus_1_090418 | ||||
 © 2001-2009, DermAtlas | Image Name: | drug_induced_lupus_4_090418 | File Type: | jpg | |
| Diagnosis: | LUPUS ERYTHEMATOSUS / LUPUS ERYTHEMATOSUS, DRUG INDUCED / DRUG REACTION | Category: | drug reaction / collagen vascular disease | ||
| Body Site: | total body / leg foot | Age: | 25 years | ||
| Contributor: | Amr Gohar, MRCPS Glasgow | ||||
| Description: | generalized discrete and confluent annular red papules and plaques with peripheral scale | ||||
| Comments: | A 25-year-old man developed a recurrent annular erythematous eruption with peripheral scaling over several months. When lesions temporarily resolved, they left greyish discoloration. The differential diagnosis included erythema annulare centrifugum, pityriasis rosea (when first seen with few lesions) , and subacute cutaneous lupus erythematosus. Initially the patient forgot that he was taking a drug for dyspepsia. Later it was found to be Lansoprazole. Skin biopsy shows hyperorthokeratosis, epidermal atrophy, hydropic degeneration of the basal cell layer, and lymphocytic infiltrate of the superficial dermis consistent with lupus. The antinuclear antibodt was positive at 1:80, while anti-Ro and anti-La antibodies were negative. Discontinuation of the Lansoprazole resulted in a complete clearance of the rash within few weeks. The pigmentary changes resolved completely. There was no recurrence of the skin lesions during a follow up period of one year. The course was typical for drug-induced lupus. | ||||
| Related Images: | All related Images drug_induced_lupus_6_090418 drug_induced_lupus_5_090418 drug_induced_lupus_3_090418 drug_induced_lupus_2_090418 drug_induced_lupus_1_090418 | ||||
 © 2001-2009, DermAtlas | Image Name: | drug_induced_lupus_5_090418 | File Type: | jpg | |
| Diagnosis: | LUPUS ERYTHEMATOSUS / LUPUS ERYTHEMATOSUS, DRUG INDUCED / DRUG REACTION | Category: | drug reaction / collagen vascular disease | ||
| Body Site: | total body / arm chest | Age: | 25 years | ||
| Contributor: | Amr Gohar, MRCPS Glasgow | ||||
| Description: | Skin biopsy shows hyperorthokeratosis, epidermal atrophy, hydropic degeneration of the basal cell layer, and lymphocytic infiltrate of the superficial dermis. | ||||
| Comments: | The histologic findings are typical of lupus. | ||||
| Related Images: | All related Images drug_induced_lupus_6_090418 drug_induced_lupus_4_090418 drug_induced_lupus_3_090418 drug_induced_lupus_2_090418 drug_induced_lupus_1_090418 | ||||
 © 2001-2009, DermAtlas | Image Name: | drug_induced_lupus_6_090418 | File Type: | jpg | |
| Diagnosis: | LUPUS ERYTHEMATOSUS / LUPUS ERYTHEMATOSUS, DRUG INDUCED / DRUG REACTION | Category: | drug reaction / collagen vascular disease | ||
| Body Site: | total body / arm chest | Age: | 25 years | ||
| Contributor: | Amr Gohar, MRCPS Glasgow | ||||
| Description: | Skin biopsy shows hyperorthokeratosis, epidermal atrophy, hydropic degeneration of the basal cell layer, and lymphocytic infiltrate of the superficial dermis. | ||||
| Comments: | The histologic findings are typical of lupus. | ||||
| Related Images: | All related Images drug_induced_lupus_5_090418 drug_induced_lupus_4_090418 drug_induced_lupus_3_090418 drug_induced_lupus_2_090418 drug_induced_lupus_1_090418 | ||||
 © 2001-2009, DermAtlas | Image Name: | lipoatrophy_1_090226 | File Type: | jpg | |
| Diagnosis: | LIPOATROPHY / LIPOATROPHIC PANNICULITIS / LIPOATROPHY, ANNULAR | Category: | collagen vascular disease / fat disorder | ||
| Body Site: | leg / calf foot / thigh | Age: | 8 years | ||
| Contributor: | Bernard Cohen, MD | ||||
| Description: | complete loss of fat of both distal lower extremities and partial lipoatrophy of the thighs. Note prominent muscles and vascular structures. | ||||
| Comments: | This healthy 8-year-old girl developed minimally painful red nodules on her ankles and lower legs 6 months ago. The lesions expanded over months and spread to her thighs. She was treated with oral steroids with rapid clearing of the red nodules but dramatic loss of subcutaneous fat. An exhaustive medical and laboratory evaluation revealed slightly enlarged thyroid gland, decreased thyroid stimulating hormone, normal thyroid hormone, and elevated anti-thyroid antibodies consistent with evolving Hashimoto thyroiditis. | ||||
| Related Images: | All related Images lipoatrophy_9_090226 lipoatrophy_8_090226 lipoatrophy_6_090226 lipoatrophy_5_090226 lipoatrophy_4_090226 lipoatrophy_3_090226 lipoatrophy_2_090226 | ||||
 © 2001-2009, DermAtlas | Image Name: | lipoatrophy_2_090226 | File Type: | jpg | |
| Diagnosis: | LIPOATROPHY / LIPOATROPHIC PANNICULITIS / LIPOATROPHY, ANNULAR | Category: | collagen vascular disease / fat disorder | ||
| Body Site: | leg / calf foot / thigh | Age: | 8 years | ||
| Contributor: | Bernard Cohen, MD | ||||
| Description: | complete loss of fat of both distal lower extremities and partial lipoatrophy of the thighs. Note prominent muscles and vascular structures. | ||||
| Comments: | This healthy 8-year-old girl developed minimally painful red nodules on her ankles and lower legs 6 months ago. The lesions expanded over months and spread to her thighs. She was treated with oral steroids with rapid clearing of the red nodules but dramatic loss of subcutaneous fat. An exhaustive medical and laboratory evaluation revealed slightly enlarged thyroid gland, decreased thyroid stimulating hormone, normal thyroid hormone, and elevated anti-thyroid antibodies consistent with evolving Hashimoto thyroiditis. | ||||
| Related Images: | All related Images lipoatrophy_9_090226 lipoatrophy_8_090226 lipoatrophy_6_090226 lipoatrophy_5_090226 lipoatrophy_4_090226 lipoatrophy_3_090226 lipoatrophy_1_090226 | ||||
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