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DermAtlas: TOTAL BODY - hypereosinophilic syndrome
© 2001-2009, DermAtlas
Image Name: hypereosinophilic_syndrome_1_090821   File Type: jpg
Diagnosis: HYPEREOSINOPHILIC SYNDROME   Category: reactive erythema /
cutaneous sign of systemic disease /
hypersensitivity
Body Site: total body / arm   Age: 40 years
Contributors: Daniel Chang
Chris Bengson
   
Description: scattered widely disseminated 0.5-1.5 cm red plaques with dusky centers
Comments: A 40-year-old woman, who was diagnosed with hypereosinophilic syndrome, was admitted on multiple occasions for angioedema of face, throat, hands, and legs, diffuse abdominal pain, and urticarial edematous plaques on her arms, trunk, and thighs. She complained of itching and then burning pain in skin lesions which persisted for 2-3 days and recurred episodically. Acute symptoms were controlled with high dose oral steroids and antihistamines. The hypereosinophilic syndromes are a heterogeneous group of disorders characterized by three common features: peripheral eosinophil count of > 1500/µL for longer than six months, evidence of end organ involvement (excluding benign eosinophilia), and absence of other causes of eosinophilia (drugs, parasites, malignancy). Skin involvement is seen in 50% of patients. Typical cutaneous features include urticaria and angioedema as well as fixed urticarial papules and plaques. Treatment of the eosinophilia usually results in improvement in cutaneous and systemic symptoms.

DermAtlas: TOTAL BODY - hypereosinophilic syndrome
© 2001-2009, DermAtlas
Image Name: hypereosinophilic_syndrome_2_090821   File Type: jpg
Diagnosis: HYPEREOSINOPHILIC SYNDROME   Category: reactive erythema /
cutaneous sign of systemic disease /
hypersensitivity
Body Site: total body / arm   Age: 40 years
Contributors: Daniel Chang
Chris Bengson
   
Description: scattered widely disseminated 0.5-1.5 cm red plaques with dusky centers
Comments: A 40-year-old woman, who was diagnosed with hypereosinophilic syndrome, was admitted on multiple occasions for angioedema of face, throat, hands, and legs, diffuse abdominal pain, and urticarial edematous plaques on her arms, trunk, and thighs. She complained of itching and then burning pain in skin lesions which persisted for 2-3 days and recurred episodically. Acute symptoms were controlled with high dose oral steroids and antihistamines. The hypereosinophilic syndromes are a heterogeneous group of disorders characterized by three common features: peripheral eosinophil count of > 1500/µL for longer than six months, evidence of end organ involvement (excluding benign eosinophilia), and absence of other causes of eosinophilia (drugs, parasites, malignancy). Skin involvement is seen in 50% of patients. Typical cutaneous features include urticaria and angioedema as well as fixed urticarial papules and plaques. Treatment of the eosinophilia usually results in improvement in cutaneous and systemic symptoms.

DermAtlas: TOTAL BODY - hypereosinophilic syndrome
© 2001-2009, DermAtlas
Image Name: hypereosinophilic_syndrome_3_090821   File Type: jpg
Diagnosis: HYPEREOSINOPHILIC SYNDROME   Category: reactive erythema /
cutaneous sign of systemic disease /
hypersensitivity
Body Site: total body / arm   Age: 40 years
Contributors: Daniel Chang
Chris Bengson
   
Description: scattered widely disseminated 0.5-1.5 cm red plaques with dusky centers
Comments: A 40-year-old woman, who was diagnosed with hypereosinophilic syndrome, was admitted on multiple occasions for angioedema of face, throat, hands, and legs, diffuse abdominal pain, and urticarial edematous plaques on her arms, trunk, and thighs. She complained of itching and then burning pain in skin lesions which persisted for 2-3 days and recurred episodically. Acute symptoms were controlled with high dose oral steroids and antihistamines. The hypereosinophilic syndromes are a heterogeneous group of disorders characterized by three common features: peripheral eosinophil count of > 1500/µL for longer than six months, evidence of end organ involvement (excluding benign eosinophilia), and absence of other causes of eosinophilia (drugs, parasites, malignancy). Skin involvement is seen in 50% of patients. Typical cutaneous features include urticaria and angioedema as well as fixed urticarial papules and plaques. Treatment of the eosinophilia usually results in improvement in cutaneous and systemic symptoms.

DermAtlas: ANKLE - pyoderma gangrenosum
© 2001-2009, DermAtlas
Image Name: pyoderma_ganrenosum_1_090617   File Type: jpg
Diagnosis: PYODERMA GANGRENOSUM   Category: ulcer /
reactive erythema
Body Site: ankle / foot / foot   Age: 12 years
Contributor: Yung Kelly    
Description: healing ulcers and scars with surrounding erythema and hyperpigmentation
Comments: This 12-year-old boy had recurrent and persistent painful ulcers on his leg and ankle. He did improve on oral prednisone, buit when the medication was tapered new lesions appeared on the ankle. He had no history of inflammatory bowel disease, underlying malignancy, sarcoidosis, or other chronic illness. An extensive medical and laboratory evaluation ( ANA, anti-dsDNA, anti-ENA, ANCA, and Cryoglobulin)was negative .

DermAtlas: TOTAL BODY - toxic epidermal necrolysis
© 2001-2009, DermAtlas
Image Name: Toxic_Epidermal_Necrolysis_3_090617   File Type: jpg
Diagnosis: TOXIC EPIDERMAL NECROLYSIS /
STEVENS-JOHNSON SYNDROME
  Category: vesiculobullous eruptions /
reactive erythema
Body Site: total body / face
neck / mouth
  Age: 24 years
Contributor: Sugathan Paramoo, MD, FRCP(Glasg)    
Description: generalized red hyperpigmented patches, crusts, vesicles, and erosions
Comments: A 24-year-old woman consulted her doctor for fever and body ache of 3 days duraton. She was prescribed Ofloxacin 400 mg twice a day aand Patracetamol. Six days later she developed extensive tenderness of her skin with brownish discoloration involving the entire body and oral mucosa.She also had malaise, head ache and generalized tender skin. After 3 weeks of oral steroids and skin care, she was markedly improved.
Related Images: Toxic_Epidermal_Necrolysis_2_090617 

DermAtlas: TOTAL BODY - toxic epidermal necrolysis
© 2001-2009, DermAtlas
Image Name: Toxic_Epidermal_Necrolysis_2_090617   File Type: jpg
Diagnosis: TOXIC EPIDERMAL NECROLYSIS /
STEVENS-JOHNSON SYNDROME
  Category: vesiculobullous eruptions /
reactive erythema
Body Site: total body / face
neck / mouth
  Age: 24 years
Contributor: Sugathan Paramoo, MD, FRCP(Glasg)    
Description: generalized red hyperpigmented patches, crusts, vesicles, and erosions
Comments: A 24-year-old woman consulted her doctor for fever and body ache of 3 days duraton. She was prescribed Ofloxacin 400 mg twice a day aand Patracetamol. Six days later she developed extensive tenderness of her skin with brownish discoloration involving the entire body and oral mucosa.She also had malaise, head ache and generalized tender skin. After 3 weeks of oral steroids and skin care, she was markedly improved.
Related Images: Toxic_Epidermal_Necrolysis_3_090617 

DermAtlas: HAND - Gianotti-Crosti syndrome
© 2001-2009, DermAtlas
Image Name: gianotti_crosti_1_090510   File Type: jpg
Diagnosis: GIANOTTI-CROSTI SYNDROME /
VIRAL INFECTIONS, EXANTHEM
  Category: infections and infestations /
reactive erythema
Body Site: hand / wrist   Age: 11 years
Contributor: Bernard Cohen, MD    
Description: symmetric scattered acral edematous 2-3 mm red papules
Comments: This healthy 11-year-old boy was evaluated for a minimally itchy diffuse papular eruption which was most dens on the extremities for 2 weeks. He had no systemic symptoms but did complain of diarrhea for 2 days before the eruption blossomed.
Related Images: All related Images  gianotti_crosti_3_090510  gianotti_crosti_2_090510 

DermAtlas: HAND - Gianotti-Crosti syndrome
© 2001-2009, DermAtlas
Image Name: gianotti_crosti_2_090510   File Type: jpg
Diagnosis: GIANOTTI-CROSTI SYNDROME /
VIRAL INFECTIONS, EXANTHEM
  Category: infections and infestations /
reactive erythema
Body Site: hand / knee
leg
  Age: 11 years
Contributor: Bernard Cohen, MD    
Description: symmetric scattered acral edematous 2-3 mm red papules
Comments: This healthy 11-year-old boy was evaluated for a minimally itchy diffuse papular eruption which was most dens on the extremities for 2 weeks. He had no systemic symptoms but did complain of diarrhea for 2 days before the eruption blossomed.
Related Images: All related Images  gianotti_crosti_3_090510  gianotti_crosti_1_090510 

DermAtlas: ARM - Gianotti-Crosti syndrome
© 2001-2009, DermAtlas
Image Name: gianotti_crosti_3_090510   File Type: jpg
Diagnosis: GIANOTTI-CROSTI SYNDROME /
VIRAL INFECTIONS, EXANTHEM
  Category: infections and infestations /
reactive erythema
Body Site: arm / wrist
elbow
  Age: 11 years
Contributor: Bernard Cohen, MD    
Description: symmetric scattered acral edematous 2-3 mm red papules
Comments: This healthy 11-year-old boy was evaluated for a minimally itchy diffuse papular eruption which was most dens on the extremities for 2 weeks. He had no systemic symptoms but did complain of diarrhea for 2 days before the eruption blossomed.
Related Images: All related Images  gianotti_crosti_2_090510  gianotti_crosti_1_090510 

DermAtlas: FACE - dermatomyositis
© 2001-2009, DermAtlas
Image Name: dermatomyositis_1_090308   File Type: jpg
Diagnosis: DERMATOMYOSITIS /
HELIOTROPE
  Category: reactive erythema /
collagen vascular disease
Body Site: face / eye lid   Age: 11 years
Contributor: Bernard Cohen, MD    
Description: symmetric red minimally scaly and edematous patches with subtle central atrophy and overlying telangiectasias
Comments: This 11-year-old boy was evaluated for red scaly patches and plaques on his eye lids, knees, elbows, and bony prominences of his hands. He complained of fatigue and had dramatic proximal muscle weakness. Magnetic resonance imaging of his legs demonstrated muscle inflammation.

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© DermAtlas, Johns Hopkins University; 2000-2009
Bernard A. Cohen, MD, Christoph U. Lehmann, MD

DermAtlas was last updated: Oct-28-2009
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