DermAtlas: Online Dermatology Image Library dermatology image,acrokeratosis paraneoplastica,Bazex syndrome,keratoderma, palmoplantar,keratoderma, palmoplantar,nail dystrophy,psoriasis

© 2001-2009, DermAtlas	*Image Name:*	acrokeratosis_neoplastica_7_071126	*File Type:*	jpg
	*Diagnosis:*	ACROKERATOSIS PARANEOPLASTICA / BAZEX SYNDROME	*Category:*
	*Body Site:*	neck	*Age:*	45 years
	*Contributor:*	Eric Ehrsam, MD
	*Description:*	enlarged cervical lymph node
	*Comments:*	A 45-year-old man was evaluated for painful psoriasiform lesions of his fingers. On examination he was noted to have acral psoriasisform and erosive lesions on his ears and toes typical of Bazex syndrome (acrokeratosis neoplastica). Palpation of the left cervical area revealed a firm lymph node which is shown on this picture. Ear, nose, and throat examination demonstrated squamous cell carcinoma of the tonsil. Bazex syndrome is most often associated with squamous cell carcinoma of the upper aerodigestive tract.
	*Related Images:*	All related Images acrokeratosis_neoplastica_1_071126 acrokeratosis_neoplastica_2_071126 acrokeratosis_neoplastica_3_071126 acrokeratosis_neoplastica_4_071126 acrokeratosis_neoplastica_5_071126 acrokeratosis_neoplastica_6_071126

© 2001-2009, DermAtlas	*Image Name:*	acrokeratosis_neoplastica_6_071126	*File Type:*	jpg
	*Diagnosis:*	ACROKERATOSIS PARANEOPLASTICA / BAZEX SYNDROME / KERATODERMA, PALMOPLANTAR	*Category:*	cutaneous sign of systemic disease / papulosquamous eruptions
	*Body Site:*	finger / hand palm	*Age:*	45 years
	*Contributor:*	Eric Ehrsam, MD
	*Description:*	painful scaly confluent plaques
	*Comments:*	A 45-year-old man was evaluated for painful psoriasiform lesions of his fingers. On examination he was noted to have acral psoriasisform and erosive lesions on his ears and toes typical of Bazex syndrome (acrokeratosis neoplastica). Palpation of the left cervical area revealed a firm lymph node which is shown on this picture. Ear, nose, and throat examination demonstrated squamous cell carcinoma of the tonsil. Bazex syndrome is most often associated with squamous cell carcinoma of the upper aerodigestive tract.
	*Related Images:*	All related Images acrokeratosis_neoplastica_1_071126 acrokeratosis_neoplastica_2_071126 acrokeratosis_neoplastica_3_071126 acrokeratosis_neoplastica_4_071126 acrokeratosis_neoplastica_5_071126 acrokeratosis_neoplastica_7_071126

© 2001-2009, DermAtlas	*Image Name:*	acrokeratosis_neoplastica_5_071126	*File Type:*	jpg
	*Diagnosis:*	ACROKERATOSIS PARANEOPLASTICA / BAZEX SYNDROME / KERATODERMA, PALMOPLANTAR	*Category:*	papulosquamous eruptions / cutaneous sign of systemic disease
	*Body Site:*	finger / hand	*Age:*	45 years
	*Contributor:*	Eric Ehrsam, MD
	*Description:*	painful scaly confluent plaques
	*Comments:*	A 45-year-old man was evaluated for painful psoriasiform lesions of his fingers. On examination he was noted to have acral psoriasisform and erosive lesions on his ears and toes typical of Bazex syndrome (acrokeratosis neoplastica). Palpation of the left cervical area revealed a firm lymph node which is shown on this picture. Ear, nose, and throat examination demonstrated squamous cell carcinoma of the tonsil. Bazex syndrome is most often associated with squamous cell carcinoma of the upper aerodigestive tract.
	*Related Images:*	All related Images acrokeratosis_neoplastica_1_071126 acrokeratosis_neoplastica_2_071126 acrokeratosis_neoplastica_3_071126 acrokeratosis_neoplastica_4_071126 acrokeratosis_neoplastica_6_071126 acrokeratosis_neoplastica_7_071126

© 2001-2009, DermAtlas	*Image Name:*	acrokeratosis_neoplastica_4_071126	*File Type:*	jpg
	*Diagnosis:*	BAZEX SYNDROME / ACROKERATOSIS PARANEOPLASTICA	*Category:*	cutaneous sign of systemic disease / papulosquamous eruptions
	*Body Site:*	toe / foot	*Age:*	45 years
	*Contributor:*	Eric Ehrsam, MD
	*Description:*	symmetric red scaly and erosive plaques with yellow scaly nails and subungual debris
	*Comments:*	A 45-year-old man was evaluated for painful psoriasiform lesions of his fingers. On examination he was noted to have acral psoriasisform and erosive lesions on his ears and toes typical of Bazex syndrome (acrokeratosis neoplastica). Palpation of the left cervical area revealed a firm lymph node which is shown on this picture. Ear, nose, and throat examination demonstrated squamous cell carcinoma of the tonsil. Bazex syndrome is most often associated with squamous cell carcinoma of the upper aerodigestive tract.
	*Related Images:*	All related Images acrokeratosis_neoplastica_1_071126 acrokeratosis_neoplastica_2_071126 acrokeratosis_neoplastica_3_071126 acrokeratosis_neoplastica_5_071126 acrokeratosis_neoplastica_6_071126 acrokeratosis_neoplastica_7_071126

© 2001-2009, DermAtlas	*Image Name:*	acrokeratosis_neoplastica_3_071126	*File Type:*	jpg
	*Diagnosis:*	BAZEX SYNDROME / ACROKERATOSIS PARANEOPLASTICA / NAIL DYSTROPHY	*Category:*	papulosquamous eruptions / cutaneous sign of systemic disease / nail disorders
	*Body Site:*	toe / foot	*Age:*	45 years
	*Contributor:*	Eric Ehrsam, MD
	*Description:*	symmetric red scaly and erosive plaques with yellow scaly nails and subungual debris
	*Comments:*	A 45-year-old man was evaluated for painful psoriasiform lesions of his fingers. On examination he was noted to have acral psoriasisform and erosive lesions on his ears and toes typical of Bazex syndrome (acrokeratosis neoplastica). Palpation of the left cervical area revealed a firm lymph node which is shown on this picture. Ear, nose, and throat examination demonstrated squamous cell carcinoma of the tonsil. Bazex syndrome is most often associated with squamous cell carcinoma of the upper aerodigestive tract.
	*Related Images:*	All related Images acrokeratosis_neoplastica_1_071126 acrokeratosis_neoplastica_2_071126 acrokeratosis_neoplastica_4_071126 acrokeratosis_neoplastica_5_071126 acrokeratosis_neoplastica_6_071126 acrokeratosis_neoplastica_7_071126

© 2001-2009, DermAtlas	*Image Name:*	acrokeratosis_neoplastica_2_071126	*File Type:*	jpg
	*Diagnosis:*	BAZEX SYNDROME / ACROKERATOSIS PARANEOPLASTICA	*Category:*	cutaneous sign of systemic disease / papulosquamous eruptions
	*Body Site:*	ear / ear, helix	*Age:*	45
	*Contributor:*	Eric Ehrsam, MD
	*Description:*	symmetric red scaly and erosive plaques
	*Comments:*	A 45-year-old man was evaluated for painful psoriasiform lesions of his fingers. On examination he was noted to have acral psoriasisform and erosive lesions on his ears and toes typical of Bazex syndrome (acrokeratosis neoplastica). Palpation of the left cervical area revealed a firm lymph node which is shown on this picture. Ear, nose, and throat examination demonstrated squamous cell carcinoma of the tonsil. Bazex syndrome is most often associated with squamous cell carcinoma of the upper aerodigestive tract.
	*Related Images:*	All related Images acrokeratosis_neoplastica_1_071126 acrokeratosis_neoplastica_3_071126 acrokeratosis_neoplastica_4_071126 acrokeratosis_neoplastica_5_071126 acrokeratosis_neoplastica_6_071126 acrokeratosis_neoplastica_7_071126

© 2001-2009, DermAtlas	*Image Name:*	acrokeratosis_neoplastica_1_071126	*File Type:*	jpg
	*Diagnosis:*	BAZEX SYNDROME / ACROKERATOSIS PARANEOPLASTICA	*Category:*	cutaneous sign of systemic disease / papulosquamous eruptions
	*Body Site:*	ear	*Age:*	45 years
	*Contributor:*	Eric Ehrsam, MD
	*Description:*	symmetric red scaly and erosive plaques
	*Comments:*	A 45-year-old man was evaluated for painful psoriasiform lesions of his fingers. On examination he was noted to have acral psoriasisform and erosive lesions on his ears and toes typical of Bazex syndrome (acrokeratosis neoplastica). Palpation of the left cervical area revealed a firm lymph node which is shown on this picture. Ear, nose, and throat examination demonstrated squamous cell carcinoma of the tonsil. Bazex syndrome is most often associated with squamous cell carcinoma of the upper aerodigestive tract.
	*Related Images:*	All related Images acrokeratosis_neoplastica_2_071126 acrokeratosis_neoplastica_3_071126 acrokeratosis_neoplastica_4_071126 acrokeratosis_neoplastica_5_071126 acrokeratosis_neoplastica_6_071126 acrokeratosis_neoplastica_7_071126

© 2001-2009, DermAtlas	*Image Name:*	Acrodermatosis_paraneoplastica_1_050328	*File Type:*	jpg
	*Diagnosis:*	ACROKERATOSIS PARANEOPLASTICA / PSORIASIS / NAIL DYSTROPHY	*Category:*	paraneoplastic syndrome / nail disorders / papulosquamous eruptions
	*Body Site:*	hand	*Age:*	73 years
	*Contributor:*	Paolo Amerio, MD, PhD
	*Description:*	symmetric red to violaceous scaly atrophic plaques with associated nail dystrophy
	*Comments:*	This 73-year-old man was evaluated for a red scaly eruption on the hands, feet, and ears for 2 months. A biopsy showed changes suggestive of psoriasis. A computed tomographic scan of the thorax revealed a nodular mass in the left lung. Histology of the lung mass demonstrated a squamous cell carcinoma, and the skin findings were felt to be consistent with acrodermatosis paranepplastica of Basex.

© 2001-2009, DermAtlas	*Image Name:*	bazex_syndrome_2_020501	*File Type:*	jpg
	*Diagnosis:*	BAZEX SYNDROME / ACROKERATOSIS PARANEOPLASTICA / NAIL DYSTROPHY	*Category:*	paraneoplastic syndrome / papulosquamous eruptions / nail disorders
	*Body Site:*	hand / foot nail, all	*Age:*	70 years
	*Contributor:*	Eric Ehrsam, MD
	*Description:*	symmetric erythematous scaly patches with yellowing and scaling of the nails
	*Comments:*	A 70 year old man developed a psoriasiform dermatitis of the fingers, toes and ears (helix). He had a destructive nail dystrophy. A few weeks later the patient also developed cervical adenopathy. Otolaryngologic investigations revealed a layngeal squamous cell carcinoma.The Bazex syndrome or acrokeratosis paraneoplastica is a rare dermatosos associated with carcinomas of the upper aerodigestive tract with possible lymph node mestastases. The cutaneous lesions occuring in the syndrome are non metastatic skin involvment. The psoriasiform lesions often precede the diagnosis of the associated malignancy, or occur simultaneously. The reapparance of skin lesions may signal a recurrence of the tumor. Treatment consists in treatment of the underlying cancer. In some cases, acitretin or oral psoralen phototherapy could be prescribed.
	*Related Images:*	bazex_syndrome_1_020501

© 2001-2009, DermAtlas	*Image Name:*	bazex_syndrome_1_020501	*File Type:*	jpg
	*Diagnosis:*	BAZEX SYNDROME / ACROKERATOSIS PARANEOPLASTICA / NAIL DYSTROPHY	*Category:*	paraneoplastic syndrome / papulosquamous eruptions / nail disorders
	*Body Site:*	ear	*Age:*	70 years
	*Contributor:*	Eric Ehrsam, MD
	*Description:*	erythematous scaly patches
	*Comments:*	A 70 year old man developed a psoriasiform dermatitis of the fingers, toes and ears (helix). He had a destructive nail dystrophy. A few weeks later the patient also developed cervical adenopathy. Otolaryngologic investigations revealed a layngeal squamous cell carcinoma. The Bazex syndrome or acrokeratosis paraneoplastica is a rare dermatosos associated with carcinomas of the upper aerodigestive tract with possible lymph node mestastases. The cutaneous lesions occuring in the syndrome are non metastatic skin involvment. The psoriasiform lesions often precede the diagnosis of the associated malignancy, or occur simultaneously. The reapparance of skin lesions may signal a recurrence of the tumor. Treatment consists in treatment of the underlying cancer. In some cases, acitretin or oral psoralen phototherapy could be prescribed.
	*Related Images:*	bazex_syndrome_2_020501

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© DermAtlas, Johns Hopkins University; 2000-2009
Bernard A. Cohen, MD, Christoph U. Lehmann, MD
DermAtlas was last updated: Oct-28-2009
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