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DermAtlas: LEG - lipoatrophy
© 2001-2009, DermAtlas
Image Name: lipoatrophy_1_090226   File Type: jpg
Diagnosis: LIPOATROPHY /
LIPOATROPHIC PANNICULITIS /
LIPOATROPHY, ANNULAR
  Category: collagen vascular disease /
fat disorder
Body Site: leg / calf
foot / thigh
  Age: 8 years
Contributor: Bernard Cohen, MD    
Description: complete loss of fat of both distal lower extremities and partial lipoatrophy of the thighs. Note prominent muscles and vascular structures.
Comments: This healthy 8-year-old girl developed minimally painful red nodules on her ankles and lower legs 6 months ago. The lesions expanded over months and spread to her thighs. She was treated with oral steroids with rapid clearing of the red nodules but dramatic loss of subcutaneous fat. An exhaustive medical and laboratory evaluation revealed slightly enlarged thyroid gland, decreased thyroid stimulating hormone, normal thyroid hormone, and elevated anti-thyroid antibodies consistent with evolving Hashimoto thyroiditis.
Related Images: All related Images  lipoatrophy_9_090226  lipoatrophy_8_090226  lipoatrophy_6_090226  lipoatrophy_5_090226  lipoatrophy_4_090226  lipoatrophy_3_090226  lipoatrophy_2_090226 

DermAtlas: LEG - lipoatrophy
© 2001-2009, DermAtlas
Image Name: lipoatrophy_2_090226   File Type: jpg
Diagnosis: LIPOATROPHY /
LIPOATROPHIC PANNICULITIS /
LIPOATROPHY, ANNULAR
  Category: collagen vascular disease /
fat disorder
Body Site: leg / calf
foot / thigh
  Age: 8 years
Contributor: Bernard Cohen, MD    
Description: complete loss of fat of both distal lower extremities and partial lipoatrophy of the thighs. Note prominent muscles and vascular structures.
Comments: This healthy 8-year-old girl developed minimally painful red nodules on her ankles and lower legs 6 months ago. The lesions expanded over months and spread to her thighs. She was treated with oral steroids with rapid clearing of the red nodules but dramatic loss of subcutaneous fat. An exhaustive medical and laboratory evaluation revealed slightly enlarged thyroid gland, decreased thyroid stimulating hormone, normal thyroid hormone, and elevated anti-thyroid antibodies consistent with evolving Hashimoto thyroiditis.
Related Images: All related Images  lipoatrophy_9_090226  lipoatrophy_8_090226  lipoatrophy_6_090226  lipoatrophy_5_090226  lipoatrophy_4_090226  lipoatrophy_3_090226  lipoatrophy_1_090226 

DermAtlas: LEG - lipoatrophy
© 2001-2009, DermAtlas
Image Name: lipoatrophy_3_090226   File Type: jpg
Diagnosis: LIPOATROPHY /
LIPOATROPHIC PANNICULITIS /
LIPOATROPHY, ANNULAR
  Category: collagen vascular disease /
fat disorder
Body Site: leg / calf
foot / thigh
  Age: 8 years
Contributor: Bernard Cohen, MD    
Description: complete loss of fat of both distal lower extremities and partial lipoatrophy of the thighs. Note prominent muscles and vascular structures.
Comments: This healthy 8-year-old girl developed minimally painful red nodules on her ankles and lower legs 6 months ago. The lesions expanded over months and spread to her thighs. She was treated with oral steroids with rapid clearing of the red nodules but dramatic loss of subcutaneous fat. An exhaustive medical and laboratory evaluation revealed slightly enlarged thyroid gland, decreased thyroid stimulating hormone, normal thyroid hormone, and elevated anti-thyroid antibodies consistent with evolving Hashimoto thyroiditis.
Related Images: All related Images  lipoatrophy_9_090226  lipoatrophy_8_090226  lipoatrophy_6_090226  lipoatrophy_5_090226  lipoatrophy_4_090226  lipoatrophy_2_090226  lipoatrophy_1_090226 

DermAtlas: LEG - lipoatrophy
© 2001-2009, DermAtlas
Image Name: lipoatrophy_4_090226   File Type: jpg
Diagnosis: LIPOATROPHY /
LIPOATROPHIC PANNICULITIS /
LIPOATROPHY, ANNULAR
  Category: collagen vascular disease /
fat disorder
Body Site: leg / calf
foot / thigh
  Age: 8 years
Contributor: Bernard Cohen, MD    
Description: complete loss of fat of both distal lower extremities and partial lipoatrophy of the thighs. Note prominent muscles and vascular structures.
Comments: This healthy 8-year-old girl developed minimally painful red nodules on her ankles and lower legs 6 months ago. The lesions expanded over months and spread to her thighs. She was treated with oral steroids with rapid clearing of the red nodules but dramatic loss of subcutaneous fat. An exhaustive medical and laboratory evaluation revealed slightly enlarged thyroid gland, decreased thyroid stimulating hormone, normal thyroid hormone, and elevated anti-thyroid antibodies consistent with evolving Hashimoto thyroiditis.
Related Images: All related Images  lipoatrophy_9_090226  lipoatrophy_8_090226  lipoatrophy_6_090226  lipoatrophy_5_090226  lipoatrophy_3_090226  lipoatrophy_2_090226  lipoatrophy_1_090226 

DermAtlas: LEG - lipoatrophy
© 2001-2009, DermAtlas
Image Name: lipoatrophy_5_090226   File Type: jpg
Diagnosis: LIPOATROPHY /
LIPOATROPHIC PANNICULITIS /
LIPOATROPHY, ANNULAR
  Category: collagen vascular disease /
fat disorder
Body Site: leg / calf
foot / thigh
  Age: 8 years
Contributor: Bernard Cohen, MD    
Description: complete loss of fat of both distal lower extremities and partial lipoatrophy of the thighs. Note prominent muscles and vascular structures.
Comments: This healthy 8-year-old girl developed minimally painful red nodules on her ankles and lower legs 6 months ago. The lesions expanded over months and spread to her thighs. She was treated with oral steroids with rapid clearing of the red nodules but dramatic loss of subcutaneous fat. An exhaustive medical and laboratory evaluation revealed slightly enlarged thyroid gland, decreased thyroid stimulating hormone, normal thyroid hormone, and elevated anti-thyroid antibodies consistent with evolving Hashimoto thyroiditis.
Related Images: All related Images  lipoatrophy_9_090226  lipoatrophy_8_090226  lipoatrophy_6_090226  lipoatrophy_4_090226  lipoatrophy_3_090226  lipoatrophy_2_090226  lipoatrophy_1_090226 

DermAtlas: LEG - lipoatrophy
© 2001-2009, DermAtlas
Image Name: lipoatrophy_6_090226   File Type: jpg
Diagnosis: LIPOATROPHY /
LIPOATROPHIC PANNICULITIS /
LIPOATROPHY, ANNULAR
  Category: collagen vascular disease /
fat disorder
Body Site: leg / calf
foot / thigh
  Age: 8 years
Contributor: Bernard Cohen, MD    
Description: complete loss of fat of both distal lower extremities and partial lipoatrophy of the thighs. Note prominent muscles and vascular structures.
Comments: This healthy 8-year-old girl developed minimally painful red nodules on her ankles and lower legs 6 months ago. The lesions expanded over months and spread to her thighs. She was treated with oral steroids with rapid clearing of the red nodules but dramatic loss of subcutaneous fat. An exhaustive medical and laboratory evaluation revealed slightly enlarged thyroid gland, decreased thyroid stimulating hormone, normal thyroid hormone, and elevated anti-thyroid antibodies consistent with evolving Hashimoto thyroiditis.
Related Images: All related Images  lipoatrophy_9_090226  lipoatrophy_8_090226  lipoatrophy_5_090226  lipoatrophy_4_090226  lipoatrophy_3_090226  lipoatrophy_2_090226  lipoatrophy_1_090226 

DermAtlas: LEG - lipoatrophy
© 2001-2009, DermAtlas
Image Name: lipoatrophy_8_090226   File Type: jpg
Diagnosis: LIPOATROPHY /
LIPOATROPHIC PANNICULITIS /
LIPOATROPHY, ANNULAR
  Category: collagen vascular disease /
fat disorder
Body Site: leg / calf
foot / thigh
  Age: 8 years
Contributor: Bernard Cohen, MD    
Description: complete loss of fat of both distal lower extremities and partial lipoatrophy of the thighs. Note prominent muscles and vascular structures.
Comments: This healthy 8-year-old girl developed minimally painful red nodules on her ankles and lower legs 6 months ago. The lesions expanded over months and spread to her thighs. She was treated with oral steroids with rapid clearing of the red nodules but dramatic loss of subcutaneous fat. An exhaustive medical and laboratory evaluation revealed slightly enlarged thyroid gland, decreased thyroid stimulating hormone, normal thyroid hormone, and elevated anti-thyroid antibodies consistent with evolving Hashimoto thyroiditis.
Related Images: All related Images  lipoatrophy_9_090226  lipoatrophy_6_090226  lipoatrophy_5_090226  lipoatrophy_4_090226  lipoatrophy_3_090226  lipoatrophy_2_090226  lipoatrophy_1_090226 

DermAtlas: LEG - lipoatrophy
© 2001-2009, DermAtlas
Image Name: lipoatrophy_9_090226   File Type: jpg
Diagnosis: LIPOATROPHY /
LIPOATROPHIC PANNICULITIS /
LIPOATROPHY, ANNULAR
  Category: collagen vascular disease /
fat disorder
Body Site: leg / calf
foot / thigh
  Age: 8 years
Contributor: Bernard Cohen, MD    
Description: complete loss of fat of both distal lower extremities and partial lipoatrophy of the thighs. Note prominent muscles and vascular structures.
Comments: This healthy 8-year-old girl developed minimally painful red nodules on her ankles and lower legs 6 months ago. The lesions expanded over months and spread to her thighs. She was treated with oral steroids with rapid clearing of the red nodules but dramatic loss of subcutaneous fat. An exhaustive medical and laboratory evaluation revealed slightly enlarged thyroid gland, decreased thyroid stimulating hormone, normal thyroid hormone, and elevated anti-thyroid antibodies consistent with evolving Hashimoto thyroiditis.
Related Images: All related Images  lipoatrophy_8_090226  lipoatrophy_6_090226  lipoatrophy_5_090226  lipoatrophy_4_090226  lipoatrophy_3_090226  lipoatrophy_2_090226  lipoatrophy_1_090226 

DermAtlas: Histology - lipoatrophy
© 2001-2009, DermAtlas
Image Name: lipoatrophy_1_071101   File Type: jpg
Diagnosis: LIPOATROPHY   Category: Iatrogenic disorders, child abuse,
Body Site: buttock   Age: 32 years
Contributor: Greg Hosler, MD, PhD    
Description: There is decreased adipose tissue within the subcutis. The septae appear thickened.
Comments: This patient was on prednisone and developed a localized depressed plaque-like area. The biopsy shows typical features of lipoatrophy. This finding can be seen with HIV, drugs and as a congenital finding.
Related Images: lipoatrophy_2_071101 

DermAtlas: Histology - lipoatrophy
© 2001-2009, DermAtlas
Image Name: lipoatrophy_2_071101   File Type: jpg
Diagnosis: LIPOATROPHY   Category: Iatrogenic disorders, child abuse,
Body Site: buttock   Age: 32 years
Contributor: Greg Hosler, MD, PhD    
Description: The fat lobules are small, making the septae appear wide. Individual adipocytes are small, with the appearance of hyalinization. There is no inflammatory infiltrate.
Comments: This patient was on prednisone and developed a localized depressed plaque-like area. The biopsy shows typical features of lipoatrophy. This finding can be seen with HIV, drugs and as a congenital finding.
Related Images: lipoatrophy_1_071101 

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© DermAtlas, Johns Hopkins University; 2000-2009
Bernard A. Cohen, MD, Christoph U. Lehmann, MD

DermAtlas was last updated: Oct-28-2009
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