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 © 2001-2009, DermAtlas | Image Name: | Incontinentia_Pigmenti_3_080714 | File Type: | jpg | |
| Diagnosis: | INCONTINENTIA PIGMENTI | Category: | vesiculobullous eruptions / genodermatosis/genetic disorder | ||
| Body Site: | leg / buttock thigh / abdomen | Age: | 13 days | ||
| Contributor: | Charles Flores, MD | ||||
| Description: | widespread linear and swirled red papules and vesicles | ||||
| Comments: | This 13-day-old girl was evaluated in the emergency room for a worsening rash. She was a full term baby delivered vaginally without complications. She appeared well, and vital signs were normal. She had widespread erythematous papules and vesicles distributed linearly on her legs and trunk as well as crusted vesicles on her scalp. There was no family medical history of skin disorders. Diagnosis was confirmed with a skin biopsy which revealed eosinophilic spongiosis. | ||||
| Related Images: | All related Images Incontinentia_Pigmenti_1_080714 Incontinentia_Pigmenti_2_080714 | ||||
 © 2001-2009, DermAtlas | Image Name: | Incontinentia_Pigmenti_2_080714 | File Type: | jpg | |
| Diagnosis: | INCONTINENTIA PIGMENTI | Category: | vesiculobullous eruptions / neonatal dermatology / genodermatosis/genetic disorder | ||
| Body Site: | scalp | Age: | 13 days | ||
| Contributor: | Charles Flores, MD | ||||
| Description: | widespread linear and swirled red papules and vesicles | ||||
| Comments: | This 13-day-old girl was evaluated in the emergency room for a worsening rash. She was a full term baby delivered vaginally without complications. She appeared well, and vital signs were normal. She had widespread erythematous papules and vesicles distributed linearly on her legs and trunk as well as crusted vesicles on her scalp. There was no family medical history of skin disorders. Diagnosis was confirmed with a skin biopsy which revealed eosinophilic spongiosis. | ||||
| Related Images: | All related Images Incontinentia_Pigmenti_1_080714 Incontinentia_Pigmenti_3_080714 | ||||
 © 2001-2009, DermAtlas | Image Name: | Incontinentia_Pigmenti_1_080714 | File Type: | jpg | |
| Diagnosis: | INCONTINENTIA PIGMENTI | Category: | vesiculobullous eruptions / Genetic Disorder / genodermatosis/genetic disorder / neonatal dermatology | ||
| Body Site: | leg / thigh abdomen / vulva (labia) | Age: | 13 days | ||
| Contributor: | Charles Flores, MD | ||||
| Description: | widespread linear and swirled red papules and vesicles | ||||
| Comments: | This 13-day-old girl was evaluated in the emergency room for a worsening rash. She was a full term baby delivered vaginally without complications. She appeared well, and vital signs were normal. She had widespread erythematous papules and vesicles distributed linearly on her legs and trunk as well as crusted vesicles on her scalp. There was no family medical history of skin disorders. Diagnosis was confirmed with a skin biopsy which revealed eosinophilic spongiosis. | ||||
| Related Images: | All related Images Incontinentia_Pigmenti_2_080714 Incontinentia_Pigmenti_3_080714 | ||||
 © 2001-2009, DermAtlas | Image Name: | Incontinentia_Pigmenti_2_070915 | File Type: | jpg | |
| Diagnosis: | INCONTINENTIA PIGMENTI | Category: | hyperpigmentation / Genetic Disorder | ||
| Body Site: | leg / total body groin / diaper area vulva (labia) | Age: | 2 months | ||
| Contributor: | Oscar Lopez Flores, MD | ||||
| Description: | asymmetric lines of Blaschko distributed hyperpigmented patches | ||||
| Comments: | This healthy 3-month-old girl had an urticarial and vesicular eruption shortly after birth before developing disseminated hyperpigmentation along lines of Blaschko. At 3 months of age her growth and development were normal. | ||||
| Related Images: | All related Images Incontinentia_Pigmenti_1_070915 Incontinentia_Pigmenti_3_070915 Incontinentia_Pigmenti_4_070915 | ||||
 © 2001-2009, DermAtlas | Image Name: | Incontinentia_Pigmenti_4_070915 | File Type: | jpg | |
| Diagnosis: | INCONTINENTIA PIGMENTI | Category: | hyperpigmentation / Genetic Disorder | ||
| Body Site: | face / total body chest / axilla (armpit) | Age: | 2 months | ||
| Contributor: | Oscar Lopez Flores, MD | ||||
| Description: | asymmetric lines of Blaschko distributed hyperpigmented patches | ||||
| Comments: | This healthy 3-month-old girl had an urticarial and vesicular eruption shortly after birth before developing disseminated hyperpigmentation along lines of Blaschko. At 3 months of age her growth and development were normal. | ||||
| Related Images: | All related Images Incontinentia_Pigmenti_1_070915 Incontinentia_Pigmenti_3_070915 Incontinentia_Pigmenti_2_070915 | ||||
 © 2001-2009, DermAtlas | Image Name: | Incontinentia_Pigmenti_3_070915 | File Type: | jpg | |
| Diagnosis: | INCONTINENTIA PIGMENTI | Category: | hyperpigmentation / Genetic Disorder | ||
| Body Site: | leg / total body | Age: | 2 months | ||
| Contributor: | Oscar Lopez Flores, MD | ||||
| Description: | asymmetric lines of Blaschko distributed hyperpigmented patches | ||||
| Comments: | This healthy 3-month-old girl had an urticarial and vesicular eruption shortly after birth before developing disseminated hyperpigmentation along lines of Blaschko. At 3 months of age her growth and development were normal. | ||||
| Related Images: | All related Images Incontinentia_Pigmenti_1_070915 Incontinentia_Pigmenti_4_070915 Incontinentia_Pigmenti_2_070915 | ||||
 © 2001-2009, DermAtlas | Image Name: | Incontinentia_Pigmenti_1_070915 | File Type: | jpg | |
| Diagnosis: | INCONTINENTIA PIGMENTI | Category: | hyperpigmentation / Genetic Disorder | ||
| Body Site: | leg / total body diaper area / groin vulva (labia) | Age: | 2 months | ||
| Contributor: | Oscar Lopez Flores, MD | ||||
| Description: | asymmetric lines of Blaschko distributed hyperpigmented patches | ||||
| Comments: | This healthy 3-month-old girl had an urticarial and vesicular eruption shortly after birth before developing disseminated hyperpigmentation along lines of Blaschko. At 3 months of age her growth and development were normal. | ||||
| Related Images: | All related Images Incontinentia_Pigmenti_3_070915 Incontinentia_Pigmenti_4_070915 Incontinentia_Pigmenti_2_070915 | ||||
 © 2001-2009, DermAtlas | Image Name: | incontinentia_pigmenti_1_061231 | File Type: | jpg | |
| Diagnosis: | INCONTINENTIA PIGMENTI | Category: | genodermatosis/genetic disorder / linear eruptions / Blaschko lines | ||
| Body Site: | abdomen / chest arm / leg genital / vulva (labia) | Age: | 3 years | ||
| Contributor: | Bernard Cohen, MD | ||||
| Description: | asymmetric linear grayish brown slightly atrophic patches following the lines of Blaschko | ||||
| Comments: | This healthy 3-year-old girl developed urticarial vesicular papules and vesicles during the first 2 weeks of life. As the lesions evolved crusted papules followed and eventually resolved leaving atrophic linear hyperpigmented patches. Note her hypoplastic and malformed teeth. | ||||
| Related Images: | incontinentia_pigmenti_2_061231 | ||||
 © 2001-2009, DermAtlas | Image Name: | incontinentia_pigmenti_2_061231 | File Type: | jpg | |
| Diagnosis: | INCONTINENTIA PIGMENTI | Category: | genodermatosis/genetic disorder / linear eruptions / Blaschko lines | ||
| Body Site: | abdomen / chest arm / leg genital / vulva (labia) | Age: | 3 years | ||
| Contributor: | Bernard Cohen, MD | ||||
| Description: | asymmetric linear grayish brown slightly atrophic patches following the lines of Blaschko | ||||
| Comments: | This healthy 3-year-old girl developed urticarial vesicular papules and vesicles during the first 2 weeks of life. As the lesions evolved crusted papules followed and eventually resolved leaving atrophic linear hyperpigmented patches. Note her hypoplastic and malformed teeth. | ||||
| Related Images: | incontinentia_pigmenti_1_061231 | ||||
 © 2001-2009, DermAtlas | Image Name: | incontinentia_pigmenti_1_070501 | File Type: | jpg | |
| Diagnosis: | INCONTINENTIA PIGMENTI | Category: | genodermatosis/genetic disorder / vesiculobullous eruptions | ||
| Body Site: | axilla (armpit) / groin vulva (labia) / leg | Age: | 4 months | ||
| Contributor: | Greg Hosler, MD, PhD | ||||
| Description: | There is marked spongiosis with exocytosis of numerous cells. There are minimal changes to the stratum corneum. | ||||
| Comments: | This is a great case, a rare dermpath find outside of courses and study sets. This 4-month-old girl developed tiny vesicles over her axillae, inguinal region, vulva and legs, present since birth. Some had mild thickening. The biopsy was submitted with a differential diagnosis of incontinentia pigmenti (IP), dermatitis herpetiformis, or bullous impetigo. IP is X-linked with a defect in NEMO. The inheritence pattern explains why this is almost exclusively found in females. Of the classic 3 stages (spongiosis, verrucous, pigmentary), this biopsy was taken from the first. The histologic differential diagnosis would include allergic contact dermatitis, arthropod bite, and bullous pemphigoid, but the clinical history seals the diagnosis..great case! | ||||
| Related Images: | incontinentia_pigmenti_2_070501 | ||||
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