DermAtlas: Online Dermatology Image Library dermatology image,mastocytosis,urticaria pigmentosa,telangiectasia macularis eruptiva perstans

© 2001-2010, DermAtlas	*Image Name:*	urticaria_pigmentosa_1_091201	*File Type:*	jpg
	*Diagnosis:*	MASTOCYTOSIS	*Category:*	cutaneous sign of systemic disease / hematology
	*Body Site:*	back	*Age:*	8 months
	*Contributor:*	Greg Hosler, MD, PhD
	*Description:*	There is an infiltrate in the dermis. The epidermis is uninvolved. The infiltrate appears in a perivascular and interstitial distribution.
	*Comments:*	This 8-month-old boy presented with scattered brown macular (and few papular) lesions on the back. There was a clinical concern for histiocytosis. Cutaneous mastocytosis can come in a variety of clinical settings - urticaria pigmentosa, solitary mastocytoma, diffuse cutaneous mastocytosis and TMEP. The histology is along a spectrum, with mastocytoma at one end, forming a nodule of mast cells, and TMEP at the other, with a mild increase of spindled mast cells around vessels. This patient is best characterized as urticaria pigmentosa and the histology is typical. Childhood cases usually do well, with clearance after a few years.
	*Related Images:*	All related Images urticaria_pigmentosa_3_091201 urticaria_pigmentosa_2_091201

© 2001-2010, DermAtlas	*Image Name:*	urticaria_pigmentosa_2_091201	*File Type:*	jpg
	*Diagnosis:*	MASTOCYTOSIS	*Category:*	cutaneous sign of systemic disease / hematology
	*Body Site:*	back	*Age:*	8 months
	*Contributor:*	Greg Hosler, MD, PhD
	*Description:*	The cells are monomorphic and have short spindled morphology. The nuclei are ovoid with smooth borders and there is moderately abundant granular amphophilic cytoplasm.
	*Comments:*	This 8-month-old boy presented with scattered brown macular (and few papular) lesions on the back. There was a clinical concern for histiocytosis. Cutaneous mastocytosis can come in a variety of clinical settings - urticaria pigmentosa, solitary mastocytoma, diffuse cutaneous mastocytosis and TMEP. The histology is along a spectrum, with mastocytoma at one end, forming a nodule of mast cells, and TMEP at the other, with a mild increase of spindled mast cells around vessels. This patient is best characterized as urticaria pigmentosa and the histology is typical. Childhood cases usually do well, with clearance after a few years.
	*Related Images:*	All related Images urticaria_pigmentosa_3_091201 urticaria_pigmentosa_1_091201

© 2001-2010, DermAtlas	*Image Name:*	urticaria_pigmentosa_3_091201	*File Type:*	jpg
	*Diagnosis:*	MASTOCYTOSIS	*Category:*	cutaneous sign of systemic disease / hematology
	*Body Site:*	back	*Age:*	8 months
	*Contributor:*	Greg Hosler, MD, PhD
	*Description:*	The cells are highlighted by a mast cell tryptase immunostain. C-kit or Giemsa can also be used.
	*Comments:*	This 8-month-old boy presented with scattered brown macular (and few papular) lesions on the back. There was a clinical concern for histiocytosis. Cutaneous mastocytosis can come in a variety of clinical settings - urticaria pigmentosa, solitary mastocytoma, diffuse cutaneous mastocytosis and TMEP. The histology is along a spectrum, with mastocytoma at one end, forming a nodule of mast cells, and TMEP at the other, with a mild increase of spindled mast cells around vessels. This patient is best characterized as urticaria pigmentosa and the histology is typical. Childhood cases usually do well, with clearance after a few years.
	*Related Images:*	All related Images urticaria_pigmentosa_2_091201 urticaria_pigmentosa_1_091201

© 2001-2010, DermAtlas	*Image Name:*	urticaria_pigmentosa_1_0910005	*File Type:*	jpg
	*Diagnosis:*	URTICARIA PIGMENTOSA / MASTOCYTOSIS	*Category:*	hyperpigmentation / lumps & bumps (plaques, nodules, tumors)
	*Body Site:*	total body / back buttock / leg	*Age:*	2 years
	*Contributor:*	Robin&Gene Stevenson
	*Description:*	multiple disseminated golden brown leathery .05-2.5 cm papules and plaques
	*Comments:*	This healthy 2-year-old boy developed multiuple golden brown papules and plaques on his trunk and extremities. A dramatic Darier sign was readily elicited by rubbing. Lesions first began to appear at 3 months of age and peaked by 18 months of age. Although the eruption remained stable until age 6, many lesions cleared over the subsequent year. He continued to grow and develop normally.
	*Related Images:*	All related Images urticaria_pigmentosa_4_0910005 urticaria_pigmentosa_3_0910005 urticaria_pigmentosa_2_0910005

© 2001-2010, DermAtlas	*Image Name:*	urticaria_pigmentosa_2_0910005	*File Type:*	jpg
	*Diagnosis:*	URTICARIA PIGMENTOSA / MASTOCYTOSIS	*Category:*	hyperpigmentation / lumps & bumps (plaques, nodules, tumors)
	*Body Site:*	total body / back buttock / leg	*Age:*	2 years
	*Contributor:*	Robin&Gene Stevenson
	*Description:*	multiple disseminated golden brown leathery .05-2.5 cm papules and plaques
	*Comments:*	This healthy 2-year-old boy developed multiuple golden brown papules and plaques on his trunk and extremities. A dramatic Darier sign was readily elicited by rubbing. Lesions first began to appear at 3 months of age and peaked by 18 months of age. Although the eruption remained stable until age 6, many lesions cleared over the subsequent year. He continued to grow and develop normally.
	*Related Images:*	All related Images urticaria_pigmentosa_4_0910005 urticaria_pigmentosa_3_0910005 urticaria_pigmentosa_1_0910005

© 2001-2010, DermAtlas	*Image Name:*	urticaria_pigmentosa_3_0910005	*File Type:*	jpg
	*Diagnosis:*	URTICARIA PIGMENTOSA / MASTOCYTOSIS	*Category:*	hyperpigmentation / lumps & bumps (plaques, nodules, tumors)
	*Body Site:*	total body / back buttock / leg	*Age:*	7 years
	*Contributor:*	Robin&Gene Stevenson
	*Description:*	subtle residual light brown macules
	*Comments:*	At age 6 the eruption began to improve, and by his seventh birthday many lesions had resolved or flattened.
	*Related Images:*	All related Images urticaria_pigmentosa_4_0910005 urticaria_pigmentosa_2_0910005 urticaria_pigmentosa_1_0910005

© 2001-2010, DermAtlas	*Image Name:*	urticaria_pigmentosa_4_0910005	*File Type:*	jpg
	*Diagnosis:*	URTICARIA PIGMENTOSA / MASTOCYTOSIS	*Category:*	hyperpigmentation / lumps & bumps (plaques, nodules, tumors)
	*Body Site:*	total body / back buttock / leg	*Age:*	7 years
	*Contributor:*	Robin&Gene Stevenson
	*Description:*	subtle residual light brown macules
	*Comments:*	At age 6 the eruption began to improve, and by his seventh birthday many lesions had resolved or flattened.
	*Related Images:*	All related Images urticaria_pigmentosa_3_0910005 urticaria_pigmentosa_2_0910005 urticaria_pigmentosa_1_0910005

© 2001-2010, DermAtlas	*Image Name:*	tmep_1_081210	*File Type:*	jpg
	*Diagnosis:*	TELANGIECTASIA MACULARIS ERUPTIVA PERSTANS / MASTOCYTOSIS	*Category:*	neoplasm, benign
	*Body Site:*	trunk	*Age:*	40 years
	*Contributor:*	Sandeep Kumar
	*Description:*	multiple generalized primarily truncal 2-4 mm partially blanching red macules
	*Comments:*	This 45-year-old man was evaluated for asymptomatic red macules on his trunk. A skin biopsy showed changes typical of telangiectasia macularis eruptiva perstans.

© 2001-2010, DermAtlas	*Image Name:*	urticaria_pigmentosa_4_070224	*File Type:*	jpg
	*Diagnosis:*	URTICARIA PIGMENTOSA / MASTOCYTOSIS	*Category:*	lumps & bumps (plaques, nodules, tumors)
	*Body Site:*	total body / leg diaper area / groin	*Age:*	6 months
	*Contributor:*	Bernard Cohen, MD
	*Description:*	disseminated grayish-brown 0.5-1.0 cm macules and slightly elevated papules, some with surrounding erythema and edema
	*Comments:*	This healthy 6-month-old girl had disseminated macules and papules typical of urticaria pigmentosa since shortly after birth. Gentle stroking resulted in hive formation.
	*Related Images:*	All related Images urticaria_pigmentosa_1_070224 urticaria_pigmentosa_2_070224 urticaria_pigmentosa_3_070224

© 2001-2010, DermAtlas	*Image Name:*	urticaria_pigmentosa_3_070224	*File Type:*	jpg
	*Diagnosis:*	URTICARIA PIGMENTOSA / MASTOCYTOSIS	*Category:*	lumps & bumps (plaques, nodules, tumors)
	*Body Site:*	total body / groin diaper area / leg	*Age:*	6 months
	*Contributor:*	Bernard Cohen, MD
	*Description:*	disseminated grayish-brown 0.5-1.0 cm macules and slightly elevated papules, some with surrounding erythema and edema
	*Comments:*	This healthy 6-month-old girl had disseminated macules and papules typical of urticaria pigmentosa since shortly after birth. Gentle stroking resulted in hive formation.
	*Related Images:*	All related Images urticaria_pigmentosa_1_070224 urticaria_pigmentosa_2_070224 urticaria_pigmentosa_4_070224