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 © 2001-2009, DermAtlas | Image Name: | porphyria_cutanea_tarda_1_080801 | File Type: | jpg | |
| Diagnosis: | PORPHYRIA CUTANEA TARDA | Category: | vesiculobullous eruptions | ||
| Body Site: | leg / hand | Age: | 73 years | ||
| Contributor: | Greg Hosler, MD, PhD | ||||
| Description: | There is a cleft in a subepidermal plane. There is focal serum and few inflammatory cells within the cleft. The dermal papillae are rigid (festooning). A significant inflammatory infiltrate is not noted in the dermis. | ||||
| Comments: | This is a pretty typical presentation for porphyria cutanea tarda. The pathology is great for it, but identical pathology can be seen with other porphyrias and pseudoporphyria. Immunofluoresence studies (not performed in this case) can aid in distinction from other pauci-inflammatory subepidermal vesiculobullous dermatoses with deposition along the BMZ and around papillary dermal vessels. Porphyrin studies are recommended for more definitive diagnosis. | ||||
| Related Images: | porphyria_cutanea_tarda_2_080801 | ||||
 © 2001-2009, DermAtlas | Image Name: | porphyria_cutanea_tarda_2_080801 | File Type: | jpg | |
| Diagnosis: | PORPHYRIA CUTANEA TARDA | Category: | vesiculobullous eruptions | ||
| Body Site: | leg / hand | Age: | 73 years | ||
| Contributor: | Greg Hosler, MD, PhD | ||||
| Description: | This view of the cleft demonstrates degenerating keratinocytes and basement membrane eosinophilic material hanging from the roof, the so-called caterpillar bodies. | ||||
| Comments: | This is a pretty typical presentation for porphyria cutanea tarda. The pathology is great for it, but identical pathology can be seen with other porphyrias and pseudoporphyria. Immunofluoresence studies (not performed in this case) can aid in distinction from other pauci-inflammatory subepidermal vesiculobullous dermatoses with deposition along the BMZ and around papillary dermal vessels. Porphyrin studies are recommended for more definitive diagnosis. | ||||
| Related Images: | porphyria_cutanea_tarda_1_080801 | ||||
 © 2001-2009, DermAtlas | Image Name: | porphyria_cutanea_tarda_1_040731 | File Type: | jpg | |
| Diagnosis: | PORPHYRIA CUTANEA TARDA / WOOD LIGHT | Category: | vesiculobullous eruptions / photosensitivity, photoexacerbated / demonstration | ||
| Body Site: | urine | Age: | 0 | ||
| Contributor: | Susan M Rabizadeh, MD | ||||
| Description: | red fluoerescence of patient's urine with normal control under Wood light | ||||
| Comments: | This 65-year-old man had a 5 year history of increased skin fragility and blistering in sunexposed areas particularly the forearms, hands, and face. Note the tense blisters, crusts, and milia on the tops of the hands. The urine fluoresced coral red under a Wood light. | ||||
| Related Images: | All related Images porphyria_cutanea_tarda_3_040731 porphyria_cutanea_tarda_2_040731 | ||||
 © 2001-2009, DermAtlas | Image Name: | porphyria_cutanea_tarda_2_040731 | File Type: | jpg | |
| Diagnosis: | PORPHYRIA CUTANEA TARDA | Category: | vesiculobullous eruptions / photosensitivity, photoexacerbated | ||
| Body Site: | hand | Age: | 0 | ||
| Contributor: | Susan M Rabizadeh, MD | ||||
| Description: | scattered milia, hemorrhagic bullae, and superficial crusts | ||||
| Comments: | This 65-year-old man had a 5 year history of increased skin fragility and blistering in sunexposed areas particularly the forearms, hands, and face. Note the tense blisters, crusts, and milia on the tops of the hands. The urine fluoresced coral red under a Wood light. | ||||
| Related Images: | All related Images porphyria_cutanea_tarda_3_040731 porphyria_cutanea_tarda_1_040731 | ||||
 © 2001-2009, DermAtlas | Image Name: | porphyria_cutanea_tarda_3_040731 | File Type: | jpg | |
| Diagnosis: | PORPHYRIA CUTANEA TARDA | Category: | vesiculobullous eruptions / photosensitivity, photoexacerbated | ||
| Body Site: | hand | Age: | 0 | ||
| Contributor: | Susan M Rabizadeh, MD | ||||
| Description: | scattered milia, hemorrhagic bullae, and superficial crusts | ||||
| Comments: | This 65-year-old man had a 5 year history of increased skin fragility and blistering in sunexposed areas particularly the forearms, hands, and face. Note the tense blisters, crusts, and milia on the tops of the hands. The urine fluoresced coral red under a Wood light. | ||||
| Related Images: | All related Images porphyria_cutanea_tarda_2_040731 porphyria_cutanea_tarda_1_040731 | ||||
 © 2001-2009, DermAtlas | Image Name: | pct_1_040426 | File Type: | jpg | |
| Diagnosis: | PORPHYRIA CUTANEA TARDA | Category: | photosensitivity, photoexacerbated / vesiculobullous eruptions | ||
| Body Site: | hand | Age: | 50 years | ||
| Contributor: | Alison Young, MD | ||||
| Description: | photodistributed symmetric erosions and hyperpigmentation | ||||
| Comments: | This 50-year-old man with hemachromatosis developed erosions on the tops of his hands for several months. Uroporphyrins were markedly elevated in a 24-hour urine analysis. | ||||
| Related Images: | All related Images pct_3_040426 pct_2_040426 | ||||
 © 2001-2009, DermAtlas | Image Name: | pct_2_040426 | File Type: | jpg | |
| Diagnosis: | PORPHYRIA CUTANEA TARDA | Category: | photosensitivity, photoexacerbated / vesiculobullous eruptions | ||
| Body Site: | hand | Age: | 50 years | ||
| Contributor: | Alison Young, MD | ||||
| Description: | photodistributed symmetric erosions and hyperpigmentation | ||||
| Comments: | This 50-year-old man with hemachromatosis developed erosions on the tops of his hands for several months. Uroporphyrins were markedly elevated in a 24-hour urine analysis. | ||||
| Related Images: | All related Images pct_3_040426 pct_1_040426 | ||||
 © 2001-2009, DermAtlas | Image Name: | pct_3_040426 | File Type: | jpg | |
| Diagnosis: | PORPHYRIA CUTANEA TARDA | Category: | photosensitivity, photoexacerbated / vesiculobullous eruptions | ||
| Body Site: | hand | Age: | 50 years | ||
| Contributor: | Alison Young, MD | ||||
| Description: | photodistributed symmetric erosions and hyperpigmentation | ||||
| Comments: | This 50-year-old man with hemachromatosis developed erosions on the tops of his hands for several months. Uroporphyrins were markedly elevated in a 24-hour urine analysis. | ||||
| Related Images: | All related Images pct_2_040426 pct_1_040426 | ||||
 © 2001-2009, DermAtlas | Image Name: | pct_2_020727 | File Type: | jpg | |
| Diagnosis: | PORPHYRIA CUTANEA TARDA | Category: | vesiculobullous eruptions / photosensitivity, photoexacerbated | ||
| Body Site: | foot | Age: | 48 years | ||
| Contributor: | Bernard Cohen, MD | ||||
| Description: | symmetric 0.5-2 cm bullae and crusts | ||||
| Comments: | This 48 year old woman developed recurrent bullae, crusts and atrophic scars on the tops of her hands and feet. She also complained of increased skin fragility and worsening of the rash during the summer months. A skin biopsy showed changes typical of porphyria cutanea tarda. She did admit to drinking at least 3-4 beers a day. She took an occasional nonsteroidal anti-inflammatory drug for arthritis but no other medications, and there was no family history of blistering disorders. | ||||
| Related Images: | pct_1_020727 | ||||
 © 2001-2009, DermAtlas | Image Name: | pct_1_020727 | File Type: | jpg | |
| Diagnosis: | PORPHYRIA CUTANEA TARDA | Category: | vesiculobullous eruptions / photosensitivity, photoexacerbated | ||
| Body Site: | hand | Age: | 48 years | ||
| Contributor: | Bernard Cohen, MD | ||||
| Description: | symmetric 0.5-2 cm bullae and crusts | ||||
| Comments: | This 48 year old woman developed recurrent bullae, crusts and atrophic scars on the tops of her hands and feet. She also complained of increased skin fragility and worsening of the rash during the summer months. A skin biopsy showed changes typical of porphyria cutanea tarda. She did admit to drinking at least 3-4 beers a day. She took an occasional nonsteroidal anti-inflammatory drug for arthritis but no other medications, and there was no family history of blistering disorders. | ||||
| Related Images: | pct_2_020727 | ||||
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