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 © 2001-2009, DermAtlas | Image Name: | pilomatricoma_1_071016 | File Type: | jpg | |
| Diagnosis: | PILOMATRICOMA / PILOMATRIXOMA | Category: | adnexal disorder / neoplasm, adnexal, follicular | ||
| Body Site: | calf / leg | Age: | 3 years | ||
| Contributor: | Katherine Puttgen, MD | ||||
| Description: | firm subcutaneous nodule | ||||
| Comments: | This healthy toddler had a several month history of asymptomatic firm subcutaneous nodules on the calf and upper arm. Biopsy revealed pilomatricoma. | ||||
 © 2001-2009, DermAtlas | Image Name: | pilomatricoma_1_070828 | File Type: | jpg | |
| Diagnosis: | PILOMATRICOMA / PILOMATRIXOMA | Category: | neoplasm, adnexal, follicular / lumps & bumps (plaques, nodules, tumors) | ||
| Body Site: | cheek / face | Age: | 9 years | ||
| Contributor: | Katherine Puttgen, MD | ||||
| Description: | 8 mm yellow white firm nodule | ||||
| Comments: | This 9-year-old boy had a 4 month history of a firm asymptomatic nodule on the right cheek which clinically resembled a pimple initially. A biopsy revealed pilomatricoma. | ||||
| Related Images: | pilomatricoma_2_070828 | ||||
 © 2001-2009, DermAtlas | Image Name: | pilomatricoma_2_070828 | File Type: | jpg | |
| Diagnosis: | PILOMATRICOMA / PILOMATRIXOMA | Category: | neoplasm, adnexal, follicular / lumps & bumps (plaques, nodules, tumors) | ||
| Body Site: | cheek / face | Age: | 9 years | ||
| Contributor: | Katherine Puttgen, MD | ||||
| Description: | 8mm yellow white firm nodule | ||||
| Comments: | This 9-year-old boy had a 4 month history of a firm asymptomatic nodule on the right cheek which clinically resembled a pimple initially. A biopsy revealed pilomatricoma. | ||||
| Related Images: | pilomatricoma_1_070828 | ||||
 © 2001-2009, DermAtlas | Image Name: | pilomatricoma_1_061120 | File Type: | jpg | |
| Diagnosis: | PILOMATRICOMA / PILOMATRIXOMA | Category: | lumps & bumps (plaques, nodules, tumors) | ||
| Body Site: | leg | Age: | 64 years | ||
| Contributor: | Eric Ehrsam, MD | ||||
| Description: | 1.0 cm violaceous nodule | ||||
| Comments: | A 64-year-old man was evaluated for a vio;aceous nodule of his right leg. The lesion was excised, and pathology revealed a pilomatricoma. | ||||
 © 2001-2009, DermAtlas | Image Name: | pilomatricoma_2_060109 | File Type: | jpg | |
| Diagnosis: | PILOMATRICOMA / PILOMATRIXOMA | Category: | neoplasm, adnexal, follicular / neoplasm, benign | ||
| Body Site: | cheek | Age: | 68 years | ||
| Contributor: | Greg Hosler, MD, PhD | ||||
| Description: | At higher power of the same lesion, one sees an interface between the cellular nodules and the keratin. The basophilic epithelium appears metabolically active, with open chromatin, conspicuous nucleoli, and scattered mitotic figures. Peripheral palisading is present. In some foci (not shown) the epithelium transitions after several layers into the eosinophilic "wet keratin". In this field they represent separate nodules. The wet keratin consists of "ghost cells", or "shadow cells", containing pale remnants of nuclei within an eosinophilic keratinous mass. The keratin is bordered by a rim of foreign-body giant cells. | ||||
| Comments: | The pilomatricoma (pilomatrixoma) is a peculiar, distinctive benign tumor. In this case of a 68-year-old woman, the clinician suspected a squamous cell carcinoma. This case is slightly unusual, because they typically appear in childhood. The head and neck is a common location, however. This lesion is thought to have a primitive follicular origin showing matrical differentiation. Malignant transformation is rare. These lesions are relatively straightforward to diagnose as few lesions show the combination of germinative epithelium admixed with "wet keratin", or keratinizing ghost cells. This phenomenon is also seen with craniopharyngiomas. In some lesions (usually with increasing age of the lesion), only the wet keratin is present, often with an associated foreign-body giant cell reaction. Pigment, calcification, and ossification can also be seen. | ||||
| Related Images: | pilomatricoma_1_060109 | ||||
 © 2001-2009, DermAtlas | Image Name: | pilomatricoma_1_060109 | File Type: | jpg | |
| Diagnosis: | PILOMATRICOMA / PILOMATRIXOMA | Category: | neoplasm, adnexal, follicular / neoplasm, benign | ||
| Body Site: | cheek | Age: | 68 years | ||
| Contributor: | Greg Hosler, MD, PhD | ||||
| Description: | Histologic sections of skin show a dermal tumor with a heterogeneous appearance. It is well circumscribed and consists of basophilic cellular nodules mixed with eosinophilic extracellular material. | ||||
| Comments: | The pilomatricoma (pilomatrixoma) is a peculiar, distinctive benign tumor. In this case of a 68-year-old woman, the clinician suspected a squamous cell carcinoma. This case is slightly unusual, because they typically appear in childhood. The head and neck is a common location, however. This lesion is thought to have a primitive follicular origin showing matrical differentiation. Malignant transformation is rare. These lesions are relatively straightforward to diagnose as few lesions show the combination of germinative epithelium admixed with "wet keratin", or keratinizing ghost cells. This phenomenon is also seen with craniopharyngiomas. In some lesions (usually with increasing age of the lesion), only the wet keratin is present, often with an associated foreign-body giant cell reaction. Pigment, calcification, and ossification can also be seen. | ||||
| Related Images: | pilomatricoma_2_060109 | ||||
 © 2001-2009, DermAtlas | Image Name: | Pilomatricoma_1_050829 | File Type: | jpg | |
| Diagnosis: | PILOMATRICOMA / CYST | Category: | surgery, pediatric | ||
| Body Site: | face | Age: | 11 years | ||
| Contributor: | Eric Sorenson, PA-C | ||||
| Description: | 2.5 cm subcutaneous yellow nodule | ||||
| Comments: | This 11-year-old girl had a 3 year history of a slowly enlarging subcutaneous nodule on the left temple. She complained of tenderness and occasional headaches resulting from the lesion. | ||||
 © 2001-2009, DermAtlas | Image Name: | pilomatrixoma_1_0401127 | File Type: | jpg | |
| Diagnosis: | PILOMATRICOMA / CYST | Category: | lumps & bumps (plaques, nodules, tumors) | ||
| Body Site: | eye lid | Age: | 12 years | ||
| Contributor: | Bernard Cohen, MD | ||||
| Description: | 4 mm light gray papule | ||||
| Comments: | A 12-year-old girl had a small gray nodule on her right upper eyelid for a year. | ||||
 © 2001-2009, DermAtlas | Image Name: | pilomatrixoma_1_021006 | File Type: | jpg | |
| Diagnosis: | PILOMATRICOMA / PILOMATRIXOMA / CYST | Category: | lumps & bumps (plaques, nodules, tumors) | ||
| Body Site: | lip / face | Age: | 7 years | ||
| Contributor: | Bernard Cohen, MD | ||||
| Description: | gray 6 mm rubbery nodule | ||||
| Comments: | This healthy 7 year old girl had a grayish nontender rubbery cyst on the left upper lip for several years. | ||||
 © 2001-2009, DermAtlas | Image Name: | pilomatrixoma_1_020904 | File Type: | jpg | |
| Diagnosis: | PILOMATRICOMA / PILOMATRIXOMA / CYST, DERMOID | Category: | lumps & bumps (plaques, nodules, tumors) / neoplasm, benign | ||
| Body Site: | cheek / face | Age: | 12 years | ||
| Contributor: | Bernard Cohen, MD | ||||
| Description: | 5 mm gray cyst | ||||
| Comments: | A 12 year old girl developed an asymptomatic gray cyst on the left cheek. Biopsy revealed a pilomatrixoma. | ||||
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