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DermAtlas: FACE - viral infections, exanthem
© 2001-2009, DermAtlas
Image Name: herpetic_plague_3_090617   File Type: jpg
Diagnosis: VIRAL INFECTIONS, EXANTHEM /
HERPES SIMPLEX VIRUS INFECTION
  Category: infections and infestations
Body Site: face / cheek   Age: 64 years
Contributor: Hsiao Lily, MD    
Description: Nearly complete remission of the red, itchingp plaque 4 days later.
Comments: This 64- year-old man suffered from recurrent Herpes simplex labialis for 10 years. Vesicles over a red plaque accompanied by burning and itching developed on the right cheek 5 days ago. The Quick Tzanck test of material obained from the vesicles revealed balloon cells with thick nuclear and cytoplasmic membranes fusing to form multinucleate giant cells. The eruption cleared in 10 days with topical antibiotic ointment, topical steroid, and 5 days of oral valacyclovir. The Quick Tzanck Test, which incorporates a modified Giemas solution, was devised by Dr. Sino as a rapid screen for the diagnosis of Herpes simplex virus infection. Staining for cytology takes only 2 minutes.
Related Images: All related Images  herpetic_plague_2_090617  herpetic_plague_1_090617 

DermAtlas: FACE - Herpes simplex virus infection
© 2001-2009, DermAtlas
Image Name: herpetic_plague_1_090617   File Type: jpg
Diagnosis: HERPES SIMPLEX VIRUS INFECTION   Category: vesiculobullous eruptions /
infections and infestations
Body Site: face / cheek   Age: 64 years
Contributor: Hsiao Lily, MD    
Description: clustered discrete and confluent 2 mm vesicles and crusts on a red edematous 2 cm plaque
Comments: This 64- year-old man suffered from recurrent Herpes simplex labialis for 10 years. Vesicles over a red plaque accompanied by burning and itching developed on the right cheek 5 days ago. The Quick Tzanck test of material obained from the vesicles revealed balloon cells with thick nuclear and cytoplasmic membranes fusing to form multinucleate giant cells. The eruption cleared in 10 days with topical antibiotic ointment, topical steroid, and 5 days of oral valacyclovir. The Quick Tzanck Test, which incorporates a modified Giemas solution, was devised by Dr. Sino as a rapid screen for the diagnosis of Herpes simplex virus infection. Staining for cytology takes only 2 minutes.
Related Images: All related Images  herpetic_plague_2_090617  herpetic_plague_3_090617 

DermAtlas: Histology - viral infections, exanthem
© 2001-2009, DermAtlas
Image Name: herpetic_plague_2_090617   File Type: jpg
Diagnosis: VIRAL INFECTIONS, EXANTHEM /
HERPES SIMPLEX VIRUS INFECTION
  Category: infections and infestations /
dermatomal eruption
Body Site: face   Age: 64 years
Contributor: Hsiao Lily, MD    
Description: The Quick Tzanck test of material obained from the vesicles revealed balloon cells with thick nuclear and cytoplasmic membranes fusing to form multinucleate giant cells.
Comments: These changes are typical but not diagnostic of Herpes simplex virus infection.
Related Images: All related Images  herpetic_plague_1_090617  herpetic_plague_3_090617 

DermAtlas: FACE - Herpes simplex virus infection
© 2001-2009, DermAtlas
Image Name: viral_infection_1_090617   File Type: jpg
Diagnosis: HERPES SIMPLEX VIRUS INFECTION   Category: infections and infestations /
vesiculobullous eruptions
Body Site: face / forehead
nose
  Age: 68 years
Contributor: Hsiao Lily, MD    
Description: clustered 2 mm skin colored to red papules and vesicles
Comments: This 68-year-old man was evaluated for a vesicular eruption on his forehead, eyelids, nose and mandible accompanied by erythema and swelling. The Quick Tzanck Test from the vesicles revealed the infiltration of numerous neutrophils, balloon cells and giant cells. Oral valacyclovir for 7 days, topical steroid over the itching areas, and antibiotic ointment for the scratched wounds were prescribed. Two days later the swelling subsided and the vesicles decreased in size. The lesions resolved completely within 10 days. Eighteen months later the patient exeprienced a recurrence. The positive Tzanck preparation helped his clinicians differentiate this eruption from bacterial infection, contact dermatitis, and drug reaction. He was on medications for hypertension and gout.
Related Images: All related Images  viral_infection_2_090617  viral_infection_3_090617 

DermAtlas: FACE - Herpes simplex virus infection
© 2001-2009, DermAtlas
Image Name: viral_infection_3_090617   File Type: jpg
Diagnosis: HERPES SIMPLEX VIRUS INFECTION   Category: infections and infestations /
vesiculobullous eruptions
Body Site: face / forehead
nose
  Age: 68 years
Contributor: Hsiao Lily, MD    
Description: eruption resolved
Comments: This 68-year-old man was evaluated for a vesicular eruption on his forehead, eyelids, nose and mandible accompanied by erythema and swelling. The Quick Tzanck Test from the vesicles revealed the infiltration of numerous neutrophils, balloon cells and giant cells. Oral valacyclovir for 7 days, topical steroid over the itching areas, and antibiotic ointment for the scratched wounds were prescribed. Two days later the swelling subsided and the vesicles decreased in size. The lesions resolved completely within 10 days. Eighteen months later the patient exeprienced a recurrence. The positive Tzanck preparation helped his clinicians differentiate this eruption from bacterial infection, contact dermatitis, and drug reaction. He was on medications for hypertension and gout.
Related Images: All related Images  viral_infection_2_090617  viral_infection_1_090617 

DermAtlas: Histology - Herpes simplex virus infection
© 2001-2009, DermAtlas
Image Name: viral_infection_2_090617   File Type: jpg
Diagnosis: HERPES SIMPLEX VIRUS INFECTION   Category: infections and infestations /
vesiculobullous eruptions
Body Site: face / forehead
nose
  Age: 68 years
Contributor: Hsiao Lily, MD    
Description: Tzanck smear by Quick Tzanck test shows neutrophils, balloon cells, and giant cells.
Comments: This 68-year-old man was evaluated for a vesicular eruption on his forehead, eyelids, nose and mandible accompanied by erythema and swelling. The Quick Tzanck Test from the vesicles revealed the infiltration of numerous neutrophils, balloon cells and giant cells. Oral valacyclovir for 7 days, topical steroid over the itching areas, and antibiotic ointment for the scratched wounds were prescribed. Two days later the swelling subsided and the vesicles decreased in size. The lesions resolved completely within 10 days. Eighteen months later the patient exeprienced a recurrence. The positive Tzanck preparation helped his clinicians differentiate this eruption from bacterial infection, contact dermatitis, and drug reaction. He was on medications for hypertension and gout.
Related Images: All related Images  viral_infection_3_090617  viral_infection_1_090617 

DermAtlas: AXILLA (ARMPIT) - Herpes simplex virus infection
© 2001-2009, DermAtlas
Image Name: granulomatous_herpes_simplex_infection_2_090626   File Type: jpg
Diagnosis: HERPES SIMPLEX VIRUS INFECTION /
HERPES SIMPLEX VIRUS INFECTION, CHRONIC /
HUMAN IMMUNODEFICIENCY VIRUS INFECTION
  Category: infections and infestations /
lumps & bumps (plaques, nodules, tumors) /
annular eruption
Body Site: axilla (armpit) / chest   Age: 0
Contributor: Adrianna Jackson    
Description: 3 cm ring of firm 2-3 mm violaceous follicular based papules
Comments: This adolescent boy with Human immunodeficiency virus infection developed an asymptomatic ring of firm violaceous papules in the right axilla. A skin biopsy showed granulomatous inflammation with changes typical of Herpes simplex virus infection, and the viral culture was positive for Herpes simplex virus type I.
Related Images: granulomatous_herpes_simplex_infection_1_090626 

DermAtlas: AXILLA (ARMPIT) - Herpes simplex virus infection
© 2001-2009, DermAtlas
Image Name: granulomatous_herpes_simplex_infection_1_090626   File Type: jpg
Diagnosis: HERPES SIMPLEX VIRUS INFECTION /
HERPES SIMPLEX VIRUS INFECTION, CHRONIC /
HUMAN IMMUNODEFICIENCY VIRUS INFECTION
  Category: infections and infestations /
lumps & bumps (plaques, nodules, tumors) /
annular eruption
Body Site: axilla (armpit) / chest   Age: 0
Contributor: Adrianna Jackson    
Description: 3 cm ring of firm 2-3 mm violaceous follicular based papules
Comments: This adolescent boy with Human immunodeficiency virus infection developed an asymptomatic ring of firm violaceous papules in the right axilla. A skin biopsy showed granulomatous inflammation with changes typical of Herpes simplex virus infection, and the viral culture was positive for Herpes simplex virus type I.
Related Images: granulomatous_herpes_simplex_infection_2_090626 

DermAtlas: FACE - Herpes simplex virus infection
© 2001-2009, DermAtlas
Image Name: eczema_herpeticum_1_090226   File Type: jpg
Diagnosis: HERPES SIMPLEX VIRUS INFECTION /
ECZEMA HERPETICUM
  Category: infections and infestations /
vesiculobullous eruptions
Body Site: face   Age: 5 years
Contributor: Bernard Cohen, MD    
Description: scattered discrete and confluent clusters of uniform 2-3 mm vesicles and crusted vesicles on a red base
Comments: This 5-year-old boy with mild atopic dermatitis developed eczema herpeticum with involvement primarily of his face and hands. The lesions were itchy and painful,and cleared within 3 days with oral acyclovir.
Related Images: All related Images  eczema_herpeticum_4_090226  eczema_herpeticum_3_090226  eczema_herpeticum_2_090226 

DermAtlas: FACE - Herpes simplex virus infection
© 2001-2009, DermAtlas
Image Name: eczema_herpeticum_2_090226   File Type: jpg
Diagnosis: HERPES SIMPLEX VIRUS INFECTION /
ECZEMA HERPETICUM
  Category: infections and infestations /
vesiculobullous eruptions
Body Site: face   Age: 5 years
Contributor: Bernard Cohen, MD    
Description: scattered discrete and confluent clusters of uniform 2-3 mm vesicles and crusted vesicles on a red base
Comments: This 5-year-old boy with mild atopic dermatitis developed eczema herpeticum with involvement primarily of his face and hands. The lesions were itchy and painful,and cleared within 3 days with oral acyclovir.
Related Images: All related Images  eczema_herpeticum_4_090226  eczema_herpeticum_3_090226  eczema_herpeticum_1_090226 

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© DermAtlas, Johns Hopkins University; 2000-2009
Bernard A. Cohen, MD, Christoph U. Lehmann, MD

DermAtlas was last updated: Oct-28-2009
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