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 © 2001-2009, DermAtlas | Image Name: | Neurofibromatosis_1_090518 | File Type: | jpg | |
| Diagnosis: | NEUROFIBROMATOSIS / CAFé AU LAIT SPOT / NEUROFIBROMA | Category: | neoplasm, benign / genodermatosis/genetic disorder / hyperpigmentation | ||
| Body Site: | chest / abdomen arm | Age: | 27 years | ||
| Contributor: | Ravi Singh | ||||
| Description: | generalized soft compressible skin colored to light brownish-purple papules and nodules | ||||
| Comments: | This 27-year-old man had an increasing number of soft tissue tumors over much of the skin surface. He had a history of hydrocephalus which was persistent despite treatment with folk remedies. | ||||
 © 2001-2009, DermAtlas | Image Name: | plexiform_neurofibroma_1_090401 | File Type: | jpg | |
| Diagnosis: | NEUROFIBROMA, PLEXIFORM / NEUROFIBROMATOSIS | Category: | neoplasm, neural / neoplasm, benign / genodermatosis/genetic disorder | ||
| Body Site: | thigh | Age: | 19 years | ||
| Contributor: | Greg Hosler, MD, PhD | ||||
| Description: | At scanning magnification, there are discrete well-circumscribed collections of spindle cells. The interval dermis has loose collagen. The epidermis is uninvolved. | ||||
| Comments: | This young man with NF-1 mutation developed a slow growing mass on his thigh. The mass was ill-defined and measured several centimeters in greatest dimension. There was a reported "bag of worms" quality to the mass, as is often the case with plexiform neurofibromas. This gross description is due to the tumor snaking around as a tube in three dimensions. When this is cut on a two dimensional slide, it appears as separate circumscribed nodules, as in this case. The tumo is made up of multiple cell types, the cells normally observed in the nerve sheath - mast cells, fibroblasts, Schwann cells, etc. The plexiform variant is virtually pathognomonic neurofibromatosis type 1. | ||||
| Related Images: | plexiform_neurofibroma_2_090401 | ||||
 © 2001-2009, DermAtlas | Image Name: | plexiform_neurofibroma_2_090401 | File Type: | jpg | |
| Diagnosis: | NEUROFIBROMA, PLEXIFORM / NEUROFIBROMATOSIS | Category: | neoplasm, neural / neoplasm, benign / genodermatosis/genetic disorder | ||
| Body Site: | thigh | Age: | 19 years | ||
| Contributor: | Greg Hosler, MD, PhD | ||||
| Description: | The tumor is made up of mulltiple cell types, including fiboblasts, Schwann cells and interspersed mast cells. These appear well-contained within the nerve sheath. Thre is no significant cytologic atypia or mitotic activity. The stroma is fibromyxoid. | ||||
| Comments: | This young man with NF-1 mutation developed a slow growing mass on his thigh. The mass was ill-defined and measured several centimeters in greatest dimension. There was a reported "bag of worms" quality to the mass, as is often the case with plexiform neurofibromas. This gross description is due to the tumor snaking around as a tube in three dimensions. When this is cut on a two dimensional slide, it appears as separate circumscribed nodules, as in this case. The tumo is made up of multiple cell types, the cells normally observed in the nerve sheath - mast cells, fibroblasts, Schwann cells, etc. The plexiform variant is virtually pathognomonic neurofibromatosis type 1. | ||||
| Related Images: | plexiform_neurofibroma_1_090401 | ||||
 © 2001-2009, DermAtlas | Image Name: | NF1_1_081007 | File Type: | jpg | |
| Diagnosis: | NEUROFIBROMATOSIS | Category: | neurologic disorder / hyperpigmentation / genodermatosis/genetic disorder | ||
| Body Site: | back | Age: | 3 years | ||
| Contributor: | Will Sorey, MD | ||||
| Description: | multiple well-demarcated uniformly brown pigmented 2 mm to 3 cm macules and patches | ||||
| Comments: | This 3-year-old boy had multiple café au lait spots since birth. His mother and brother have an established diagnosis of neurofibromatosis type 1. The case was prepared by University of Mississippi Year 4 Medical Student Sarah M H Jones. | ||||
 © 2001-2009, DermAtlas | Image Name: | neurofibromatosis_1_080424 | File Type: | jpg | |
| Diagnosis: | NEUROFIBROMATOSIS | Category: | neoplasm, benign / genodermatosis/genetic disorder | ||
| Body Site: | chest / total body / abdomen | Age: | 70 years | ||
| Contributor: | Syed Imam, MD | ||||
| Description: | generalized 5 mm-5 cm soft spongy skin colored to slightlyt pink tumors | ||||
| Comments: | A 70-year-old man had generalized slowly progressive neurofibromas without neurologic complications. His daughter was also affected. | ||||
| Related Images: | All related Images neurofibromatosis_9_080424 neurofibromatosis_8_080424 neurofibromatosis_7_080424 neurofibromatosis_6_080424 neurofibromatosis_5_080424 neurofibromatosis_4_080424 neurofibromatosis_3_080424 neurofibromatosis_2_080424 | ||||
 © 2001-2009, DermAtlas | Image Name: | neurofibromatosis_2_080424 | File Type: | jpg | |
| Diagnosis: | NEUROFIBROMATOSIS | Category: | neoplasm, benign / genodermatosis/genetic disorder | ||
| Body Site: | chest / total body / abdomen | Age: | 70 years | ||
| Contributor: | Syed Imam, MD | ||||
| Description: | generalized 5 mm-5 cm soft spongy skin colored to slightlyt pink tumors | ||||
| Comments: | A 70-year-old man had generalized slowly progressive neurofibromas without neurologic complications. His daughter was also affected. | ||||
| Related Images: | All related Images neurofibromatosis_9_080424 neurofibromatosis_8_080424 neurofibromatosis_7_080424 neurofibromatosis_6_080424 neurofibromatosis_5_080424 neurofibromatosis_4_080424 neurofibromatosis_3_080424 neurofibromatosis_1_080424 | ||||
 © 2001-2009, DermAtlas | Image Name: | neurofibromatosis_3_080424 | File Type: | jpg | |
| Diagnosis: | NEUROFIBROMATOSIS | Category: | neoplasm, benign / genodermatosis/genetic disorder | ||
| Body Site: | chest / total body arm / abdomen | Age: | 70 years | ||
| Contributor: | Syed Imam, MD | ||||
| Description: | generalized 5 mm-5 cm soft spongy skin colored to slightlyt pink tumors | ||||
| Comments: | A 70-year-old man had generalized slowly progressive neurofibromas without neurologic complications. His daughter was also affected. | ||||
| Related Images: | All related Images neurofibromatosis_9_080424 neurofibromatosis_8_080424 neurofibromatosis_7_080424 neurofibromatosis_6_080424 neurofibromatosis_5_080424 neurofibromatosis_4_080424 neurofibromatosis_2_080424 neurofibromatosis_1_080424 | ||||
 © 2001-2009, DermAtlas | Image Name: | neurofibromatosis_4_080424 | File Type: | jpg | |
| Diagnosis: | NEUROFIBROMATOSIS | Category: | neoplasm, benign / genodermatosis/genetic disorder | ||
| Body Site: | back / total body | Age: | 70 years | ||
| Contributor: | Syed Imam, MD | ||||
| Description: | generalized 5 mm-5 cm soft spongy skin colored to slightlyt pink tumors | ||||
| Comments: | A 70-year-old man had generalized slowly progressive neurofibromas without neurologic complications. His daughter was also affected. | ||||
| Related Images: | All related Images neurofibromatosis_9_080424 neurofibromatosis_8_080424 neurofibromatosis_7_080424 neurofibromatosis_6_080424 neurofibromatosis_5_080424 neurofibromatosis_3_080424 neurofibromatosis_2_080424 neurofibromatosis_1_080424 | ||||
 © 2001-2009, DermAtlas | Image Name: | neurofibromatosis_5_080424 | File Type: | jpg | |
| Diagnosis: | NEUROFIBROMATOSIS | Category: | neoplasm, benign / genodermatosis/genetic disorder | ||
| Body Site: | back / total body shoulder | Age: | 70 years | ||
| Contributor: | Syed Imam, MD | ||||
| Description: | generalized 5 mm-5 cm soft spongy skin colored to slightlyt pink tumors | ||||
| Comments: | A 70-year-old man had generalized slowly progressive neurofibromas without neurologic complications. His daughter was also affected. | ||||
| Related Images: | All related Images neurofibromatosis_9_080424 neurofibromatosis_8_080424 neurofibromatosis_7_080424 neurofibromatosis_6_080424 neurofibromatosis_4_080424 neurofibromatosis_3_080424 neurofibromatosis_2_080424 neurofibromatosis_1_080424 | ||||
 © 2001-2009, DermAtlas | Image Name: | neurofibromatosis_6_080424 | File Type: | jpg | |
| Diagnosis: | NEUROFIBROMATOSIS | Category: | neoplasm, benign / genodermatosis/genetic disorder | ||
| Body Site: | chest / total body arm / abdomen | Age: | 70 years | ||
| Contributor: | Syed Imam, MD | ||||
| Description: | generalized 5 mm-5 cm soft spongy skin colored to slightlyt pink tumors | ||||
| Comments: | A 70-year-old man had generalized slowly progressive neurofibromas without neurologic complications. His daughter was also affected. | ||||
| Related Images: | All related Images neurofibromatosis_9_080424 neurofibromatosis_8_080424 neurofibromatosis_7_080424 neurofibromatosis_5_080424 neurofibromatosis_4_080424 neurofibromatosis_3_080424 neurofibromatosis_2_080424 neurofibromatosis_1_080424 | ||||
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