Paget Disease (extramammary) - DermAtlas

Contributor

Emily Desantis, MD

Diagnosis

Paget disease (extramammary)

Body Site

scrotum

Age

73 years

Pigmentation

light

Organization

discrete

Color

red

Morphology

plaqulous (plaque / nodule / tumor)

Pattern

solitary

Comments

This is a typical example of extramammary Paget disease. The differential diagnosis would include squamous cell carcinoma in situ (Bowen disease), melanoma in situ, and other carcinomas with pagetoid growth. A diagnosis of Paget disease is favored when positive for intracellular mucin, cytokeratin, and negative for s100, as in this case.

Description

A mucicarmine stain confirms the presence of intracellular mucin within the atypical cells (pink color).

Image Added

4/14/2006 8:42:54

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Other Resources

PubMed Medline Plus Medscape

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