Drug Reaction, Keratoderma, Palmoplantar, Drug Reaction, Calcium Channel Blocker - DermAtlas

Contributor

Simon Yoo, MD

Diagnosis

drug reaction keratoderma, palmoplantar drug reaction, calcium channel blocker

Body Site

palm hand

Age

48 years

Pigmentation

light

Organization

confluent

Color

red yellow

Morphology

papulosquamous (bump, scale)

Pattern

symmetric acral (centripetal - extremity predominant)

Comments

This 48 year old man developed a progressive keratoderma on his palms shortly after starting oral verapamil for hypertension. The plaques and erythema worsened as the dose was increased and decreased and cleared when the dose was decreased and finally discontinued. A punch biopsy from the palm showed a perivascular lymphocytic infiltrate with basilar vaculopathy and dyskeratosis.

Description

symmetric thick yellow scaly plaques on a red base

Image Added

11/17/2002 18:51:29

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Other Resources

PubMed Medline Plus Medscape

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