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Contributor

Adam Mamalek

Diagnosis

Langerhans cell histiocytosis

Body Site

total body

Age

7 days

Pigmentation

medium

Organization

scattered

Color

red purple

Morphology

papule

Pattern

generalized, disseminated symmetric

Comments

These findings support the diagnosis of Langerhans cell histiocytosis. The negative staining for S100 was probably a false negative study.

Description

Immunohistochemical stains demonstrated that the large mononuclear cells were reactive with CD1a immunostain but only dimly reactive for S100 protein. Ki67 highlighted a rare cell within the infiltrate. Staining for TdT was negative.

Categories

neonatal dermatology neoplasm, malignant

Image Added

10/10/2005 8:07:27

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Other Resources

PubMed Medline Plus Medscape

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