Langerhans Cell Histiocytosis - DermAtlas

Contributor

Adam Mamalek

Diagnosis

Langerhans cell histiocytosis

Body Site

total body

Age

7 days

Pigmentation

medium

Organization

scattered

Color

red purple

Morphology

papule

Pattern

generalized, disseminated symmetric

Comments

These changes are typical of Langerhans cell histiocytosis.

Description

Histologic sections of skin show numerous large mononuclear cells containing reniform nuclei with prominent nucleoli and abundant pink cytoplasm infiltrating the epidermis. The cells were also seen infiltrating the dermis in a perivascular and periadnexal pattern. The area of epidermal infiltration was also spongiotic and contained hemorrhage and overlying seroinflammatory crust. A few admixed lymphocytes were also seen in the dermis. The adjacent epidermis was otherwise unremarkable.

Image Added

10/10/2005 8:07:22

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Other Resources

PubMed Medline Plus Medscape

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