Bullous Pemphigoid - DermAtlas - Dermatology Image Atlas

Contributor

Greg Hosler, MD, PhD

Diagnosis

bullous pemphigoid

Body Site

arm

Age

70 years

Pigmentation

light

Organization

flexural surfaces

Color

red

Morphology

vesiculobullous (blister, pustule)

Pattern

symmetric

Comments

This 70-year-old man developed multiple tense bullae, with an erythematous base, over his arms. His oral cavity was not involved. This is a typical presentation and histology for bullous pemphigoid. This case also demonstrated heavy linear IgG and C3 along the epidermal basement membrane zone (not shown). The antigens are related to the hemidesmosomes, BP230 and BP180.

Description

Histologic sections of skin show separation of the epidermis from the dermis in a subepidermal plane. The blister cavity contains serum and inflammatory cells. The subjacent dermis appears to have an infiltrate as well as background solar elastosis. The flanking epidermis shows mild spongiosis.

Image Added

3/14/2006 22:58:56

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Other Resources

PubMed Medline Plus Medscape

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