Epidermolytic Acanthoma, Epidermolytic Hyperkeratosis - DermAtlas

Contributor

Greg Hosler, MD, PhD

Diagnosis

epidermolytic acanthoma epidermolytic hyperkeratosis

Body Site

chest

Age

64 years

Pigmentation

medium

Organization

discrete warty

Color

red

Morphology

papule

Pattern

solitary

Comments

Epidermolytic hyperkeratosis may present as a solitary lesion (acanthoma), as in this case, as an incidental finding on histology, i.e. within a dysplastic nevus, or as a generalized phenomenon like in bullous congenital ichthyosiform erythroderma. There appears to be an association with KRT1 and KRT10 keratin defects. Although histologically characteristic, the differential diagnosis would also include viral warts.

Description

Histologic sections of skin show epidermal acanthosis, papillomatosis, and hyperkeratosis. Hypergranulosis with keratinocytic clear cell change is also noted, even at this low power.

Image Added

3/21/2006 22:31:16

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PubMed Medline Plus Medscape

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