Paget Disease (extramammary) - DermAtlas

Contributor

Emily Desantis, MD

Diagnosis

Paget disease (extramammary)

Body Site

scrotum

Age

73 years

Pigmentation

light

Organization

discrete

Color

red

Morphology

plaqulous (plaque / nodule / tumor)

Pattern

solitary

Comments

This is a typical example of extramammary Paget disease. The differential diagnosis would include squamous cell carcinoma in situ (Bowen disease), melanoma in situ, and other carcinomas with pagetoid growth. A diagnosis of Paget disease is favored when positive for intracellular mucin, cytokeratin, and negative for s100, as in this case.

Description

Histologic sections of skin show an acanthotic epidermis containing single cells and nests of large epithelioid mononuclear cells at all levels of the epidermis (upper panel). The cells have vesicular nuclei, prominent nucleoli, and abundant pale vacuolated cytoplasm.

Image Added

4/14/2006 8:42:56

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Other Resources

PubMed Medline Plus Medscape

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