This 62-year-old man, who received a bone marrow transplant following chemotherapy for leukemia, developed chronic poikiloderma and lichenoid dermatitis thought to be consistent with chronic graft versus host disease. Interestingly, when lymphocyte markers were checked, there were increased numbers of recipient lymphocytes noted in the inflammatory infiltrate on skin biopsy when the skin disease worsened when the dose of immunosuppressives was reduced. This suggested that the disease was related to host lymphocyte injury of altered host antigens possibly induced by immunosupprressive medications.
Description
generalized poikiloderma with scale, atrophy, reticulated blanching erythema, and mottled hyperpigmentation, nail atrophy, scale, yellowing
