This 64- year-old man suffered from recurrent Herpes simplex labialis for 10 years. Vesicles over a red plaque accompanied by burning and itching developed on the right cheek 5 days ago. The Quick Tzanck test of material obained from the vesicles revealed balloon cells with thick nuclear and cytoplasmic membranes fusing to form multinucleate giant cells. The eruption cleared in 10 days with topical antibiotic ointment, topical steroid, and 5 days of oral valacyclovir. The Quick Tzanck Test, which incorporates a modified Giemas solution, was devised by Dr. Sino as a rapid screen for the diagnosis of Herpes simplex virus infection. Staining for cytology takes only 2 minutes.
clustered discrete and confluent 2 mm vesicles and crusts on a red edematous 2 cm plaque