Ichthyosis, Acquired - DermAtlas - Dermatology Image Atlas

Contributor

Greg Hosler, MD, PhD

Diagnosis

ichthyosis, acquired

Body Site

buttock leg

Age

41 years

Pigmentation

dark

Organization

confluent

Color

brown

Morphology

plaqulous (plaque / nodule / tumor)

Pattern

symmetric acral (centripetal - extremity predominant)

Comments

This 41-year-old African-American female with rheumatoid arthritis and fibromyalgia developed a diffuse ichthyosiform eruption over the course of 3-4 months. Acquired ichthyosis has been associated with sarcoidosis, as well as HIV, connective tissue disease, drugs, and malignancies. The histology of ichthyosis is subtle, and falls into the "normal skin" differential, requiring clinical history. The histology resembles ichthyosis vulgaris, showing thickened compact orthokeratosis and an attenuated granular layer, as in this case.

Description

Histologic sections of skin show hypogranulosis and overlying compact hyperorthokeratosis. The biopsy otherwise looks normal.

Image Added

2/6/2006 23:41:37

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Other Resources

PubMed Medline Plus Medscape

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