Langerhans Cell Histiocytosis - DermAtlas

Contributor

Bernard Cohen, MD

Diagnosis

Langerhans cell histiocytosis

Body Site

ear neck scalp

Age

10 months

Pigmentation

light

Organization

discrete confluent

Color

red purple

Morphology

plaqulous (plaque / nodule / tumor)

Pattern

symmetric intertrigenous (creases)

Comments

This 10-month-old boy had a 2 month history of vomiting and diarrhea, weight loss, and skin eruption. A skin biopsy showed histiocytic infiltration of the epidermis with crusting, hemorrhage, and erosions. The cells in the epidermis were positive for S100 and CD1a typical of Langerhans cells. He also had Langerhans cell infiltration of the stomach and small bowel.

Description

symmetric indurated plaques with overlying red hemorrhagic papules and patches with erosions and crusting

Image Added

3/30/2008 11:49:55

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Other Resources

PubMed Medline Plus Medscape

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