This healthy 3-month-old boy developed diffuse blisters on his trunk, extremities, and face during the newborn period. Although the eruption was initially diagnosed as Herpes simplex Virus infection and treated with acyclovir, the diagnosis of urticaria pigmentosa became apparent when the initial blisters cleared and leathery brown papules and plaques emerged. A Darier sign could be readily demonstrated. This case prepared by second year medical student at Univ of Mississippi School of Medicine Sarah M.H.Jones.
An African American male infant presented with diffuse blisters on the trunk, extremities, and face that assumed a brown papular appearance as the blisters resolved. Due to a contact history, the lesions were initially suspected to be caused by herpes simplex II virus and Acyclovir therapy was initiated. The lesions, however, would flare into blister form with mechanical irritation; therefore he was diagnosed with Urticaria Pigmentosa of Cutaneous Mastocytosis. This case prepared by Sarah M.H.Jones, M-2 at Univ of MS School of Medicine.