This young adult presented with clusters of flech-colored papules on the face. Some lesions had a central umbilication. This is a very typical case of Molluscum Contagiosum (MC). It is spread by direct contact and may be sexually tramsmitted. The histology is pathognomonic, classic in this case. There is a central umbilicated area with numerous Molluscum (Henderson-Patterson) bodies. MC is in the pox family of double-stranded DNA viruses. Other members of this family also can have large eosinophilic inclusions, but not to the degree and in the configuration of MC. The epithelium is histologically altered in MC, making a diagnosis possible without the present of the viral inclusions. Recent studies have demonstrated the abnormal expression of certain keratins (for example 16).
This view shows the characteristic Molluscum (or Henderson-Patterson) bodies. These are large cytoplsmic eosinophlic viral inclusions. There is coarsening of the keratohyaline granules in this example.