Pemphigus, Paraneoplastic - DermAtlas - Dermatology Image Atlas

Contributor

Alison Rhein, MD

Diagnosis

pemphigus, paraneoplastic

Body Site

mouth lip tongue

Age

33 years

Pigmentation

dark

Organization

Color

red

Morphology

ulcerated (erosion / ulcer)

Pattern

symmetric

Comments

This 33 year old man was evaluated for chronic painful hemorrhagic crusted eroded lips. He was unable to eat and became cachectic. Multiple cultures for Herpes simplex virus were negative, and several empiric courses of acyclovir produced no improvement. Serologic tests fro syphilis and Human immunodeficiency virus were negative. Skin biopsy and direct immunofluorescence showed changes typical of paraneoplastic pemphigus. A systemic evaluation revealed a large Castleman tumor in his chest. Excision of the tumor resulted in complete remission of the pemphigus.

Description

hemorrhagic crusted lips and eroded tongue

Image Added

3/14/2002 21:54:32

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Other Resources

PubMed Medline Plus Medscape

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