Vasculitis, Vasculitis, Leukocytoclastic, Cryoglobulinemia - DermAtlas

Contributor

Raquel Charles

Diagnosis

vasculitis vasculitis, leukocytoclastic cryoglobulinemia

Body Site

leg shin

Age

43 years

Pigmentation

light

Organization

grouped, clustered

Color

red purple

Morphology

papulosquamous (bump, scale)

Pattern

symmetric acral (centripetal - extremity predominant)

Comments

This 43 year old woman was admitted to the hospital for evaluation of acute worsening of leg pain and weakness that started 10 months earlier. During her hospitalization she developed purpuric papules on her lower legs. A skin biopsy showed a leukocytoclastic vasculitis and direct immunofluorescence demonstrated IgG, M and C3 in dermal blood vessels consistent with polyarteritis nodosa. Laboratory studies revealed cryoglobulinemia with a monoclonal IgM kappa and polyclonal IgG, A, and M. These findings were most consistent with mixed cryoglobulinemia that is often associated with collagen vascular disease. For more details see the cme discussion.

Description

multiple symmetric 2-3 mm purpuric papules

Image Added

11/15/2002 0:22:46

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Other Resources

PubMed Medline Plus Medscape

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